Diffuse alveolar hemorrhage in patients with hematological malignancies: HRCT patterns of pulmonary involvement and disease course
- PMID: 23313188
- DOI: 10.1016/j.clinimag.2012.11.005
Diffuse alveolar hemorrhage in patients with hematological malignancies: HRCT patterns of pulmonary involvement and disease course
Abstract
Objective: To analyze high-resolution computed tomography (HRCT) patterns of lung involvement and disease course in patients with hematological malignancies experiencing diffuse alveolar hemorrhage (DAH) after chemotherapy ± allogeneic stem cell transplantation (allo-SCT).
Materials and methods: Sixteen patients experiencing DAH after chemotherapy ± allo-SCT were enrolled. A total of 74 computed tomography (CT) scans obtained before, during, and after onset of DAH were evaluated retrospectively.
Results: CT features of DAH are each, by oneself, nonspecific. However, conjoint bilateral, diffuse, and dependent ground glass opacity ± crazy paving, accompanied by airspace bronchograms, should suggest this complication. The HRCT course comprises a wide range of trends that are not predictive for patient's outcome, but progression of parenchymal consolidations at follow up was more often detrimental.
Copyright © 2013 Elsevier Inc. All rights reserved.
Similar articles
-
Pulmonary Leptospirosis With Diffuse Alveolar Hemorrhage: High-Resolution Computed Tomographic Findings in 16 Patients.J Comput Assist Tomogr. 2016 Jan-Feb;40(1):91-5. doi: 10.1097/RCT.0000000000000318. J Comput Assist Tomogr. 2016. PMID: 26418542
-
Increasing incidence of diffuse alveolar hemorrhage following allogeneic bone marrow transplantation: cryptic etiology and uncertain therapy.Bone Marrow Transplant. 2000 Sep;26(5):539-43. doi: 10.1038/sj.bmt.1702546. Bone Marrow Transplant. 2000. PMID: 11019844
-
Radiological aspects of diffuse alveolar haemorrhage.Radiol Med. 2008 Feb;113(1):16-28. doi: 10.1007/s11547-008-0229-x. Epub 2008 Feb 25. Radiol Med. 2008. PMID: 18338124 English, Italian.
-
Risk and triggering factors for diffuse alveolar hemorrhage in primary antiphospholipid syndrome. An observational follow-up study and a systematic review of the literature.Semin Arthritis Rheum. 2025 Jun;72:152697. doi: 10.1016/j.semarthrit.2025.152697. Epub 2025 Feb 25. Semin Arthritis Rheum. 2025. PMID: 40056479
-
Antiphospholipid antibodies as a cause of pulmonary capillaritis and diffuse alveolar hemorrhage: a case series and literature review.Semin Arthritis Rheum. 2005 Dec;35(3):154-65. doi: 10.1016/j.semarthrit.2005.05.006. Semin Arthritis Rheum. 2005. PMID: 16325656 Review.
Cited by
-
Risk factors and outcomes of diffuse alveolar haemorrhage after allogeneic haematopoietic stem cell transplantation.Bone Marrow Transplant. 2021 Sep;56(9):2097-2107. doi: 10.1038/s41409-021-01293-y. Epub 2021 Apr 12. Bone Marrow Transplant. 2021. PMID: 33846561 Free PMC article.
-
Bronchoscopy in children with diffuse alveolar hemorrhage under general anesthesia with spontaneous respiration by face mask ventilation.Medicine (Baltimore). 2024 Nov 15;103(46):e40582. doi: 10.1097/MD.0000000000040582. Medicine (Baltimore). 2024. PMID: 39560565 Free PMC article.
-
Corticosteroid Therapy for Diffuse Alveolar Hemorrhage with Respiratory Failure in Hematologic Malignancies: A Retrospective Cohort Study.Ther Clin Risk Manag. 2025 May 17;21:705-714. doi: 10.2147/TCRM.S520299. eCollection 2025. Ther Clin Risk Manag. 2025. PMID: 40405916 Free PMC article.
-
Emphysema: an ignored radiologic sign of diffuse alveolar hemorrhage.BMC Pediatr. 2025 Jul 2;25(1):513. doi: 10.1186/s12887-025-05850-y. BMC Pediatr. 2025. PMID: 40604497 Free PMC article.
-
Diffuse Alveolar Hemorrhage Occurring Suddenly in a Diabetic Patient With Asthma Exacerbation.Cureus. 2024 Jan 8;16(1):e51893. doi: 10.7759/cureus.51893. eCollection 2024 Jan. Cureus. 2024. PMID: 38333472 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
