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Meta-Analysis
. 2013 Mar;148(3):366-73.
doi: 10.1177/0194599812470427. Epub 2013 Jan 11.

Macrolide therapy for chronic rhinosinusitis: a meta-analysis

Melissa A Pynnonen  1 , Giri Venkatraman, Greg E Davis
Affiliations
Meta-Analysis

Macrolide therapy for chronic rhinosinusitis: a meta-analysis

Melissa A Pynnonen et al. Otolaryngol Head Neck Surg. 2013 Mar.

Abstract

Objective: The objective of this study was to systematically review patient-reported outcomes of long-term macrolide therapy, compared with any other treatment, for adults with chronic rhinosinusitis.

Data sources: EMBASE and PubMed databases were searched in October 2011.

Review methods: A total of 1216 citations were screened initially by a single author, 23 full-text manuscripts were evaluated by 2 authors using structured data abstraction forms to assess for inclusion criteria and study quality, and 3 studies were included in the final review.

Results: This review finds that 3 prospective clinical studies have evaluated the effect of macrolide therapy for chronic rhinosinusitis. Based on the limited data, there is limited scientific evidence to support the use of long-term macrolide therapy for chronic rhinosinusitis.

Conclusion: Further clinical research is needed to determine whether there may be a subgroup effect based on the underlying inflammatory disease process.

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Figures

Figure 1
Figure 1
Flow Chart of Study Selection
Figure 2
Figure 2
Sinonasal Outcome Test Change Scores at 6 weeks
Figure 3
Figure 3
Sinonasal Outcome Test Change Scores at 12 weeks
Figure 4
Figure 4
Sinonasal Outcome Test Change Scores at 24 weeks
Figure 5
Figure 5
Patient Response Scale at 12 weeks
See this image and copyright information in PMC

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