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. 2013 Mar;24(2):118-9.
doi: 10.1097/MBC.0b013e32835707cd.

Role of methylenetetrahydrofolate reductase A1298C polymorphism in cerebral venous thrombosis

Najiba Fekih-Mrissa  1 , Sarra Klai, Meriem Mrad, Jamel Zaouali, Aycha Sayeh, Brahim Nsiri, Nasreddine Gritli, Ridha Mrissa
Affiliations

Role of methylenetetrahydrofolate reductase A1298C polymorphism in cerebral venous thrombosis

Najiba Fekih-Mrissa et al. Blood Coagul Fibrinolysis. 2013 Mar.

Abstract

The association between the methylenetetrahydrofolate reductase (MTHFR) gene and cerebral venous thrombosis (CVT) remains controversial. This study principally investigated the potential role of the MTHFR A1298C variant and CVT. The genotyping of the A1298C variant of the MTHFR gene was performed in 35 CVT patients and 200 healthy controls. The frequency of A1298C genotype among CVT patients was significantly higher compared with controls (P < 10(-3)), suggesting an association between this polymorphism and CVT. To our knowledge, there are no previous reports assessing the correlation between the MTHFR A1298C variant and CVT. Large study populations would be required to understand the contribution of this marker in the risk of CVT.

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