doi: 10.1038/nchembio.1164.
Epub 2013 Jan 13.
An unsaturated aliphatic alcohol as a natural ligand for a mouse odorant receptor
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- PMID: 23314914
- DOI: 10.1038/nchembio.1164
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An unsaturated aliphatic alcohol as a natural ligand for a mouse odorant receptor
Nat Chem Biol.
2013 Mar.
Abstract
We report the identification of a physiological receptor-volatile pair in the mouse olfactory system. By activity-guided fractionation of exocrine gland extracts and subsequent chemical analysis, (Z)-5-tetradecen-1-ol was identified as a natural ligand for a mouse odorant receptor. (Z)-5-tetradecen-1-ol is excreted into male mouse urine under androgen control and enhances urine attractiveness to female mice. This report is to our knowledge the first to describe natural product-based deorphanization of an odorant receptor.
Comment in
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Receptors: Chemical courtship in mice.Nat Chem Biol. 2013 Mar;9(3):140-1. doi: 10.1038/nchembio.1180. Nat Chem Biol. 2013. PMID: 23416397 No abstract available.
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