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. 2013 Apr;207(7):1166-70.
doi: 10.1093/infdis/jit015. Epub 2013 Jan 11.

Plasma viral loads during early HIV-1 infection are similar in subtype C- and non-subtype C-infected African seroconverters

Mary S Campbell  1 , Erin M Kahle, Connie Celum, Jairam R Lingappa, Saidi Kapiga, Andrew Mujugira, Nelly R Mugo, Kenneth H Fife, James I Mullins, Jared M Baeten; Partners in Prevention HSV/HIV Transmission Study Team
Collaborators, Affiliations

Plasma viral loads during early HIV-1 infection are similar in subtype C- and non-subtype C-infected African seroconverters

Mary S Campbell et al. J Infect Dis. 2013 Apr.

Abstract

Recent data suggest that infection with human immunodeficiency virus type 1 (HIV-1) subtype C results in prolonged high-level viremia (>5 log10 copies/mL) during early infection. We examined the relationship between HIV-1 subtype and plasma viremia among 153 African seroconverters. Mean setpoint viral loads were similar for C and non-C subtypes: 4.36 vs 4.42 log10 copies/mL (P = .61). The proportion of subtype C-infected participants with viral loads >5 log10 copies/mL was not greater than the proportion for those with non-C infection. Our data do not support the hypothesis that higher early viral load accounts for the rapid spread of HIV-1 subtype C in southern Africa.

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Comment in

  • Reply to Neogi et al.
    Campbell MS, Kahle EM, Baeten JM. Campbell MS, et al. J Infect Dis. 2013 Sep 1;208(5):867-8. doi: 10.1093/infdis/jit259. Epub 2013 Jun 10. J Infect Dis. 2013. PMID: 23757336 Free PMC article. No abstract available.
  • High viremia in HIV-1 subtype C infection and spread of the epidemic.
    Neogi U, Palchaudhuri R, Shet A. Neogi U, et al. J Infect Dis. 2013 Sep 1;208(5):866-7. doi: 10.1093/infdis/jit258. Epub 2013 Jun 10. J Infect Dis. 2013. PMID: 23757339 No abstract available.

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