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. 2012 Dec 3:2:168.
doi: 10.3389/fonc.2012.00168. eCollection 2012.

Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers

Susan Pyne  1 , Joanne Edwards, Jan Ohotski, Nigel J Pyne
Affiliations

Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers

Susan Pyne et al. Front Oncol. .

Abstract

There is substantial evidence for a role in cancer of the bioactive lipid sphingosine 1-phosphate (S1P), the enzyme sphingosine kinase 1 (that catalyses S1P formation) and S1P-specific G protein-coupled receptors. This perspective highlights recent findings demonstrating that sphingosine kinase 1 and S1P receptors are new important biomarkers for detection of early cancer and progression to aggressive cancer. The impact of the sub-cellular distribution of S1P metabolizing enzymes and S1P receptors and their spatial functional interaction with oncogenes is considered with respect to prognostic outcome. These findings suggest that S1P, in addition to being a biomarker of clinical prognosis, might also be a new therapeutic target for intervention in cancer.

Keywords: disease-specific survival; estrogen receptor; recurrence; sphingosine 1-phosphate; triple negative breast cancer.

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Figures

FIGURE 1
FIGURE 1
Kaplan–Meier plots showing the effect of high cytoplasmic S1P4 expression on (A) disease-specific survival; (B) recurrence in ER, PgR, HER2 negative breast cancer patients. (C) Box plot showing the correlation between node status and cytoplasmic S1P4 expression.
See this image and copyright information in PMC

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