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. 2013 Jun;18(3):222-8.
doi: 10.1111/hel.12036. Epub 2013 Jan 15.

The effect of Helicobacter pylori infection on iron stores and iron deficiency in urban Alaska Native adults

Karen Miernyk  1 , Dana Bruden, Carolyn Zanis, Brian McMahon, Frank Sacco, Thomas Hennessy, Alan Parkinson, Michael Bruce
Affiliations

The effect of Helicobacter pylori infection on iron stores and iron deficiency in urban Alaska Native adults

Karen Miernyk et al. Helicobacter. 2013 Jun.

Abstract

Background: Helicobacter pylori (H. pylori) infection has been correlated with low serum ferritin and iron deficiency. As a secondary analysis of a study of H. pylori reinfection, we investigated the association of H. pylori infection and the effect of its eradication on serum ferritin and iron deficiency.

Methods: Alaska Native adults undergoing esophagogastroduodenoscopy had sera collected and a (13) C urea breath test (UBT) was performed. Those H. pylori positive were treated with an antibiotic regimen; those who tested negative 2 months after treatment were evaluated at 4, 6, 12, and 24 months by UBT and serum ferritin with an immunoradiometric assay. We excluded persons from further analysis if they were prescribed iron by their provider.

Results: We measured serum ferritin for 241 persons; 121/241 were H. pylori positive. The geometric mean ferritin (GMF) for persons with and without H. pylori infection was 37 μg/L and 50 μg/L, respectively (p = .04). At enrollment, 19/121 H. pylori-positive persons had iron deficiency compared with 8/120 H. pylori negative (p = .02). Among 66 persons tested at 24 months, the GMF was higher at 24 months (49.6 μg/L) versus enrollment (36.5 μg/L; p = .02). Six of 11 persons with iron deficiency at enrollment no longer had iron deficiency and had a higher GMF (p = .02) 24 months after treatment.

Conclusions: H. pylori infection was correlated with lower serum ferritin and iron deficiency. After H. pylori eradication, serum ferritin increased and approximately half of persons resolved their iron deficiency. Testing for H. pylori infection and subsequent treatment of those positive could be considered in persons with unexplained iron deficiency.

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Conflict of interest statement

Competing interests: The authors have no competing interests.

References

    1. Clark SF. Iron deficiency anemia. Nutr Clin Pract. 2008 Apr-May;23(2):128–141. - PubMed
    1. Beard J, Stoltzfus R. Iron deficiency anemia: reexamining the nature and magnitude of the public health problem. J Nutr; Proceedings of a conference; May 21–24, 2000; Belmont, USA. 2001. p. 563S.
    1. Haas JD, Brownlie Tt. Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship. J Nutr. 2001 Feb;131(2S-2):676S–688S. discussion 88S–90S. - PubMed
    1. Rasmussen K. Is There a Causal Relationship between Iron Deficiency or Iron-Deficiency Anemia and Weight at Birth, Length of Gestation and Perinatal Mortality? J Nutr. 2001 Feb;131(2S-2):590S–601S. discussion S-3S. - PubMed
    1. Grantham-McGregor S, Ani C. A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr. 2001 Feb;131(2S-2):649S–666S. discussion 66S–68S. - PubMed

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