Review
doi: 10.1016/j.gde.2012.12.005.
Epub 2013 Jan 11.
mTOR in aging, metabolism, and cancer
Affiliations
- PMID: 23317514
- DOI: 10.1016/j.gde.2012.12.005
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Review
mTOR in aging, metabolism, and cancer
Curr Opin Genet Dev.
2013 Feb.
Abstract
The target of rapamycin (TOR) is a highly conserved serine/threonine kinase that is part of two structurally and functionally distinct complexes, TORC1 and TORC2. In multicellular organisms, TOR regulates cell growth and metabolism in response to nutrients, growth factors and cellular energy. Deregulation of TOR signaling alters whole body metabolism and causes age-related disease. This review describes the most recent advances in TOR signaling with a particular focus on mammalian TOR (mTOR) in metabolic tissues vis-a-vis aging, obesity, type 2 diabetes, and cancer.
Copyright © 2012 Elsevier Ltd. All rights reserved.
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