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Review
. 2013 Feb;23(1):53-62.
doi: 10.1016/j.gde.2012.12.005. Epub 2013 Jan 11.

mTOR in aging, metabolism, and cancer

Marion Cornu  1 , Verena Albert, Michael N Hall
Affiliations
Review

mTOR in aging, metabolism, and cancer

Marion Cornu et al. Curr Opin Genet Dev. 2013 Feb.

Abstract

The target of rapamycin (TOR) is a highly conserved serine/threonine kinase that is part of two structurally and functionally distinct complexes, TORC1 and TORC2. In multicellular organisms, TOR regulates cell growth and metabolism in response to nutrients, growth factors and cellular energy. Deregulation of TOR signaling alters whole body metabolism and causes age-related disease. This review describes the most recent advances in TOR signaling with a particular focus on mammalian TOR (mTOR) in metabolic tissues vis-a-vis aging, obesity, type 2 diabetes, and cancer.

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