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Comment
. 2013 Jan;3(1):14-9.
doi: 10.1158/2159-8290.CD-12-0520.

Unpicking the combination lock for mutant BRAF and RAS melanomas

Bissan Al-Lazikani  1 , Paul Workman
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Comment

Unpicking the combination lock for mutant BRAF and RAS melanomas

Bissan Al-Lazikani et al. Cancer Discov. 2013 Jan.

Abstract

Large-scale, unbiased combinatorial drug screening has been used to identify effective genotype-selective therapeutic combinations that show promising activity in preclinical models of mutant BRAF andRAS melanoma that are resistant to the clinical BRAF inhibitor vemurafenib.

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