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Randomized Controlled Trial
. 2013 Jan 16:12:17.
doi: 10.1186/1475-2840-12-17.

Lipoprotein lipase links vitamin D, insulin resistance, and type 2 diabetes: a cross-sectional epidemiological study

Yifan Huang  1 , Xiaoxia Li, Maoqing Wang, Hua Ning, Lima A, Ying Li, Changhao Sun
Affiliations
Randomized Controlled Trial

Lipoprotein lipase links vitamin D, insulin resistance, and type 2 diabetes: a cross-sectional epidemiological study

Yifan Huang et al. Cardiovasc Diabetol. .

Abstract

Background: Lipoprotein lipase (LPL) and serum 25-hydroxyvitamin D [25(OH)D] play important roles in the regulation of lipid metabolism. Although dyslipidemia is associated with insulin resistance (IR) and type 2 diabetes (T2D), there are limited data available regarding the relationship of LPL and 25(OH)D to IR and T2D at a population level. The objective of the present study is to investigate the associations of LPL and 25(OH)D with IR and T2D in a Chinese population.

Methods: The study cohort consisted of 2708 subjects (1326 males, 1382 females; mean age 48.5 ± 12.6 years) in main communities of Harbin, China. Serum 25(OH)D, LPL, free fatty acids (FFAs), fasting glucose (FG), fasting insulin, lipid profile, apoA and apoB concentrations were measured.

Results: Serum 25(OH)D concentration was positively associated with LPL (β = 0.168, P < 0.001). LPL was inversely associated with IR and T2D. Subjects in the lowest quartile of LPL had the highest risk of IR [odds ratio (OR) = 1.85, 95% CI = 1.22-2.68] and T2D (OR = 1.65, 95% CI = 1.14-2.38). Serum 25(OH)D was also inversely associated with IR and T2D. Vitamin D deficiency [25(OH)D < 20 ng/ml] was associated with an increasing risk of IR (OR = 1.91, 95% CI = 1.23-2.76) and T2D (OR = 2.06, 95% CI = 1.37-3.24). The associations of 25(OH)D with IR and T2D were attenuated by further adjustment for LPL.

Conclusions: LPL is associated with serum 25(OH)D, IR and T2D in the Chinese population. These results suggest a potential mediating role of LPL in the associations of 25(OH)D with IR and T2D.

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Figures

Figure 1
Figure 1
Putative scheme of effect of vitamin D on insulin resistance and type 2 diabetes. Vitamin D deficiency influences the pathogenesis of insulin resistance and type 2 diabetes by direct effect such as decreased binding to vitamin D receptor (VDR), and indirect effect such as aberrant calcium flux. Reductive serum 25(OH)D concentration was accompanied with decreased LPL and increased TG in our study, which might be associated with insulin resistance and type 2 diabetes.
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