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Editorial
. 2013 Feb 1;12(3):381-2.
doi: 10.4161/cc.23549. Epub 2013 Jan 16.

Inactivation of myofibroblasts during regression of liver fibrosis

Tatiana Kisseleva, David A Brenner
Editorial

Inactivation of myofibroblasts during regression of liver fibrosis

Tatiana Kisseleva et al. Cell Cycle. .
No abstract available

Keywords: hepatic stellate cells; inactivation into a quiescent-like phenotype; liver fibrosis; myofibroblasts; regression of liver fibrosis.

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Figures

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Figure 1. Study design to determine the cell fate of aHSCs during regression of CCl4-induced liver fibrosis. (A) Cre-loxP-based genetic labeling marks the fate of Col-α1(I)-expressing aHSCs/ myofibroblasts in Col-α1(I)Cre-YFP mice generated by crossing Col-α1(I)Cre and Rosa26f/f-YFP mice. (B) Col-α1(I)Cre-YFP mice were subjected to CCl4-induced liver injury (1.5 mo) then recuperated upon cessation of injuring agent (for 1 mo). Mice were sacrificed, and livers were analyzed for the presence of Vitamin A+ YFP+ and Vitamin A+ YFP- HSCs. (C) CCl4 induces qHSC activation into aHSCs/myofibroblasts in Col-α1(I)Cre-YFP mice. After CCl4 withdrawal, some aHSCs apoptose, while some inactivate (YFP+ iHSCs number < 100% of aHSCs).
See this image and copyright information in PMC

Comment on

  • Kisseleva T, Cong M, Paik Y, Scholten D, Jiang C, Benner C, et al. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci USA. 2012;109:9448–53. doi: 10.1073/pnas.1201840109.

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