. 2013 Jun;162(6):1120-4, 1124.e1.

doi: 10.1016/j.jpeds.2012.11.089. Epub 2013 Jan 13.

Late-onset sepsis in very low birth weight infants from singleton and multiple-gestation births

Nansi S Boghossian¹, Grier P Page, Edward F Bell, Barbara J Stoll, Jeffrey C Murray, C Michael Cotten, Seetha Shankaran, Michele C Walsh, Abbot R Laptook, Nancy S Newman, Ellen C Hale, Scott A McDonald, Abhik Das, Rosemary D Higgins; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

Collaborators, Affiliations

Collaborators

Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network:
Barbara J Stoll, Avroy A Fanaroff, Edward F Bell, Shahnaz Duara, Ronald N Goldberg, Abbot R Laptook, William Oh, Seetha Shankaran, Michele C Walsh, Abhik Das, W Kenneth Poole, Linda L Wright, Rosemary D Higgins, Nancy S Newman, Ellen C Hale, Alan H Jobe, Michael S Caplan, Angelita M Hensman, Avroy A Fanaroff, Kurt Schibler, Edward F Donovan, Kate Bridges, Barbara Alexander, Cathy Grisby, Marcia Worley Mersmann, Holly L Mincey, Jody Hessling, Kathy J Auten, Kimberley A Fisher, Katherine A Foy, Sandra Grimes, Melody B Lohmeyer, David P Carlton, Ann M Blackwelder, Linda L Wright, Stephanie Wilson Archer, Brenda B Poindexter, James A Lemons, Dianne E Herron, Lucy C Miller, Leslie Dawn Wilson, Betty K Hastings, Jeanette O'Donnell Auman, Carolyn Petrie Huitema, Kristin Zaterka-Baxter, Krisa P Van Meurs, David K Stevenson, Marian M Adams, M Bethany Ball, Melinda S Proud, Andrew W Palmquist, Ivan D Frantz 3rd, Brenda L MacKinnon, Ellen Nylen, Waldemar A Carlo, Namasivayam Ambalavanan, Monica V Collins, Shirley S Cosby, Neil N Finer, Paul R Wozniak, Maynard R Rasmussen, Kathy Arnell, Clarence Demetrio, Chris Henderson, Wade Rich, John A Widness, Karen J Johnson, Nancy J Krutzfield, Shahnaz Duara, Ruth Everett-Thomas, Kristi L Watterberg, Lu-Ann Papile, Conra Backstrom Lacy, Dale L Phelps, Linda J Reubens, Mary Rowan, Erica Burnell, Pablo J Sánchez, Charles R Rosenfeld, Walid A Salhab, Gaynelle Hensley, Melissa H Leps, Nancy A Miller, Alicia Guzman, Susie Madison, Kathleen A Kennedy, Jon E Tyson, Esther G Akpa, Patty A Cluff, Beverly Foley Harris, Claudia I Franco, Anna E Lis, Sarah Martin, Georgia E McDavid, Maegan C Simmons, Patti Pierce Tate, Roger G Faix, Bradley A Yoder, Karen A Osborne, Jill Burnett, Jennifer J Jensen, Cynthia Spencer, Kimberlee Weaver-Lewis, T Michael O'Shea, Nancy J Peters, Rebecca Bara, Geraldine Muran, Richard A Ehrenkranz, Harris C Jacobs, Patricia Cervone, Patricia Gettner, Monica Konstantino, JoAnn Poulsen, Janet Taft

Affiliation

¹ Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA.

PMID: 23324523
PMCID: PMC3633723
DOI: 10.1016/j.jpeds.2012.11.089

Late-onset sepsis in very low birth weight infants from singleton and multiple-gestation births

Nansi S Boghossian et al. J Pediatr. 2013 Jun.

. 2013 Jun;162(6):1120-4, 1124.e1.

doi: 10.1016/j.jpeds.2012.11.089. Epub 2013 Jan 13.

Authors

Collaborators

Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network:
Barbara J Stoll, Avroy A Fanaroff, Edward F Bell, Shahnaz Duara, Ronald N Goldberg, Abbot R Laptook, William Oh, Seetha Shankaran, Michele C Walsh, Abhik Das, W Kenneth Poole, Linda L Wright, Rosemary D Higgins, Nancy S Newman, Ellen C Hale, Alan H Jobe, Michael S Caplan, Angelita M Hensman, Avroy A Fanaroff, Kurt Schibler, Edward F Donovan, Kate Bridges, Barbara Alexander, Cathy Grisby, Marcia Worley Mersmann, Holly L Mincey, Jody Hessling, Kathy J Auten, Kimberley A Fisher, Katherine A Foy, Sandra Grimes, Melody B Lohmeyer, David P Carlton, Ann M Blackwelder, Linda L Wright, Stephanie Wilson Archer, Brenda B Poindexter, James A Lemons, Dianne E Herron, Lucy C Miller, Leslie Dawn Wilson, Betty K Hastings, Jeanette O'Donnell Auman, Carolyn Petrie Huitema, Kristin Zaterka-Baxter, Krisa P Van Meurs, David K Stevenson, Marian M Adams, M Bethany Ball, Melinda S Proud, Andrew W Palmquist, Ivan D Frantz 3rd, Brenda L MacKinnon, Ellen Nylen, Waldemar A Carlo, Namasivayam Ambalavanan, Monica V Collins, Shirley S Cosby, Neil N Finer, Paul R Wozniak, Maynard R Rasmussen, Kathy Arnell, Clarence Demetrio, Chris Henderson, Wade Rich, John A Widness, Karen J Johnson, Nancy J Krutzfield, Shahnaz Duara, Ruth Everett-Thomas, Kristi L Watterberg, Lu-Ann Papile, Conra Backstrom Lacy, Dale L Phelps, Linda J Reubens, Mary Rowan, Erica Burnell, Pablo J Sánchez, Charles R Rosenfeld, Walid A Salhab, Gaynelle Hensley, Melissa H Leps, Nancy A Miller, Alicia Guzman, Susie Madison, Kathleen A Kennedy, Jon E Tyson, Esther G Akpa, Patty A Cluff, Beverly Foley Harris, Claudia I Franco, Anna E Lis, Sarah Martin, Georgia E McDavid, Maegan C Simmons, Patti Pierce Tate, Roger G Faix, Bradley A Yoder, Karen A Osborne, Jill Burnett, Jennifer J Jensen, Cynthia Spencer, Kimberlee Weaver-Lewis, T Michael O'Shea, Nancy J Peters, Rebecca Bara, Geraldine Muran, Richard A Ehrenkranz, Harris C Jacobs, Patricia Cervone, Patricia Gettner, Monica Konstantino, JoAnn Poulsen, Janet Taft

Affiliation

¹ Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA.

PMID: 23324523
PMCID: PMC3633723
DOI: 10.1016/j.jpeds.2012.11.089

Abstract

Objectives: To describe and compare the incidence of late-onset sepsis (LOS) and demographic and clinical characteristics associated with LOS in very low birth weight (VLBW) infants from singleton and multiple births, and to examine the heritability of susceptibility to LOS among VLBW twins by comparing same-sex and unlike-sex twin pairs.

Study design: The study group comprised infants with birth weight 401-1500 g seen at clinical centers of the Eunice Kennedy Shriver National Institute of Child and Human Development Neonatal Research Network between 2002 and 2008. Only the first episode of LOS was included in our analysis. Stepwise logistic regression models were fitted separately for singleton and multiple pregnancies to examine the maternal and neonatal factors associated with LOS. LOS due solely to gram-negative bacteria in singleton and multiple pregnancies was also examined in separate models. The heritability of LOS was estimated by examining the concordance of LOS in twins from same-sex and unlike-sex pairs.

Results: LOS occurred in 25.0% (3797 of 15,178) of singleton and 22.6% (1196 of 5294) of multiple-birth VLBW infants. Coagulase-negative staphylococci were the most common infecting organisms, accounting for 53.2% of all LOS episodes in singletons and 49.2% in multiples. Escherichia coli and Klebsiella species were the most commonly isolated gram-negative organisms, and Candida albicans was the most commonly isolated fungus. Concordance of LOS did not differ significantly between same-sex and unlike-sex twin pairs.

Conclusion: LOS remains a common problem in VLBW infants. The incidence of LOS is similar for singleton and multiple-birth infants. The similar concordance of LOS in same-sex and unlike-sex twin pairs provides no evidence that susceptibility to LOS among VLBW infants is genetically determined.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

**Figure**
Distribution of age (days) of the first episode of late-onset sepsis among very low birth weight singletons and multiples (including twins) in the NICHD Neonatal Research Network, 2002–2008.

See this image and copyright information in PMC

References

1. Stoll BJ, Hansen N. Infections in VLBW infants: studies from the NICHD Neonatal Research Network. Semin Perinatol. 2003;27:293–301. - PubMed
1. Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, et al. Outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics. 2010;126:443–56. - PMC - PubMed
1. Alexander GR, Himes JH, Kaufman RB, Mor J, Kogan M. A United States national reference for fetal growth. Obstet Gynecol. 1996;87:163–8. - PubMed
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1. Smith C. Concordance in twins: methods and interpretation. Am J Hum Genet. 1974;26:454–66. - PMC - PubMed

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Late-onset sepsis in very low birth weight infants from singleton and multiple-gestation births

Collaborators

Affiliation

Late-onset sepsis in very low birth weight infants from singleton and multiple-gestation births

Authors

Collaborators

Affiliation

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical