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Comment
. 2013 Jan 29;110(5):1571-2.
doi: 10.1073/pnas.1220841110. Epub 2013 Jan 16.

miR-122 is more than a shield for the hepatitis C virus genome

Adolfo García-Sastre  1 , Matthew J Evans
Affiliations
Comment

miR-122 is more than a shield for the hepatitis C virus genome

Adolfo García-Sastre et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
miR-122 impacts HCV RNA stability and HCV RNA replication. Illustration of HCV RNA replication within membrane bound vesicles in the host cell cytoplasm. Also shown is a zoomed-in view of the 5′ end of the HCV genomic RNA with two bound miR-122 molecules. Cytoplasmic, but not P body-associated, Xrn1 degrades the HCV genomic RNA, perhaps after the 5′ triphosphate is modified by a pyrophosphatase. Although binding of miR-122 to the HCV RNA inhibits Xrn1 degradation, miR-122 also exerts another effect to enhance HCV RNA replication.
See this image and copyright information in PMC

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