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Review
. 2013 Jan 16;5(1):226-40.
doi: 10.3390/v5010226.

Potential cellular functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus

Danielle Westhoff Smith  1 , Bill Sugden
Affiliations
Review

Potential cellular functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus

Danielle Westhoff Smith et al. Viruses. .

Abstract

Epstein-Barr Nuclear Antigen 1 (EBNA1) is a multifunctional protein encoded by EBV. EBNA1's role in maintaining EBV in latently proliferating cells, by mediating EBV genome synthesis and nonrandom partitioning to daughter cells, as well as regulating viral gene transcription, is well characterized. Less understood are the roles of EBNA1 in affecting the host cell to provide selective advantages to those cells that harbor EBV. In this review we will focus on the interactions between EBNA1 and the host cell that may provide EBV-infected cells selective advantages beyond the maintenance of EBV.

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Figures

Figure 1
Figure 1
A Structural Representation of Epstein-Barr Nuclear Antigen 1 (EBNA1) with the Protein Interacting Domains and Functional Motifs discussed in this review. The Brackets give citations identifying these domains and motifs. The Amino Acid (AA) positions of each domain are noted. G-R notes the glycine-arginine rich regions within the DNA Looping/Linking regions. G-G-A notes the glycine-alanine repeat region. NLS notes the Nuclear Localization Signal.
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References

    1. Young L.S., Murray P.G. Epstein-barr virus and oncogenesis: From latent genes to tumours. Oncogene. 2003;22:5108–5121. doi: 10.1038/sj.onc.1206556. - DOI - PubMed
    1. Ambinder R.F., Shah W.A., Rawlins D.R., Hayward G.S., Hayward S.D. Definition of the sequence requirements for binding of the ebna-1 protein to its palindromic target sites in epstein-barr virus DNA. J. Virol. 1990;64:2369–2379. - PMC - PubMed
    1. Frappier L., O'Donnell M. Overproduction, purification, and characterization of ebna1, the origin binding protein of epstein-barr virus. J. Biol. Chem. 1991;266:7819–7826. - PubMed
    1. Schepers A., Ritzi M., Bousset K., Kremmer E., Yates J.L., Harwood J., Diffley J.F., Hammerschmidt W. Human origin recognition complex binds to the region of the latent origin of DNA replication of epstein-barr virus. EMBO J. 2001;20:4588–4602. doi: 10.1093/emboj/20.16.4588. - DOI - PMC - PubMed
    1. Sears J., Kolman J., Wahl G.M., Aiyar A. Metaphase chromosome tethering is necessary for the DNA synthesis and maintenance of orip plasmids but is insufficient for transcription activation by epstein-barr nuclear antigen 1. J. Virol. 2003;77:11767–11780. doi: 10.1128/JVI.77.21.11767-11780.2003. - DOI - PMC - PubMed

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