An overview of the highly pathogenic H5N1 influenza virus

doi:10.1007/s12250-013-3294-9

Review

. 2013 Feb;28(1):3-15.

doi: 10.1007/s12250-013-3294-9. Epub 2013 Jan 16.

An overview of the highly pathogenic H5N1 influenza virus

Jingchuan Yin¹, Shi Liu, Ying Zhu

Affiliations

PMID: 23325419
PMCID: PMC7090813
DOI: 10.1007/s12250-013-3294-9

Review

An overview of the highly pathogenic H5N1 influenza virus

Jingchuan Yin et al. Virol Sin. 2013 Feb.

. 2013 Feb;28(1):3-15.

doi: 10.1007/s12250-013-3294-9. Epub 2013 Jan 16.

Authors

Jingchuan Yin¹, Shi Liu, Ying Zhu

Affiliation

¹ The State Key laboratory of Virology and College of Life Sciences, Wuhan University, Wuhan 430072, China.

PMID: 23325419
PMCID: PMC7090813
DOI: 10.1007/s12250-013-3294-9

Abstract

Since the first human case of H5N1 avian influenza virus infection was reported in 1997, this highly pathogenic virus has infected hundreds of people around the world and resulted in many deaths. The ability of H5N1 to cross species boundaries, and the presence of polymorphisms that enhance virulence, present challenges to developing clear strategies to prevent the pandemic spread of this highly pathogenic avian influenza (HPAI) virus. This review summarizes the current understanding of, and recent research on, the avian influenza H5N1 virus, including transmission, virulence, pathogenesis, clinical characteristics, treatment and prevention.

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References

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1. Baskin C. R., Bielefeldt-Ohmann H., Tumpey T. M., Sabourin P. J., Long J. P., Garcia-Sastre A., Tolnay A. E., Albrecht R., Pyles J. A., Olson P. H., Aicher L. D., Rosenzweig E. R., Murali-Krishna K., Clark E. A., Kotur M. S., Fornek J. L., Proll S., Palermo R. E., Sabourin C. L., Katze M. G. Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus. Proc Natl Acad Sci U S A. 2009;106:3455–3460. doi: 10.1073/pnas.0813234106. - DOI - PMC - PubMed
1. Beigel J. H., Farrar J., Han A. M., Hayden F. G., Hyer R., de Jong M. D., Lochindarat S., Nguyen T. K., Nguyen T. H., Tran T. H., Nicoll A., Touch S., Yuen K. Y., Writing Committee of the World Health Organization Consultation on Human Influenza A H Avian influenza A (H5N1) infection in humans. N Engl J Med. 2005;353:1374–1385. doi: 10.1056/NEJMra052211. - DOI - PubMed
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[1] Abdelwhab E. M., Hafez H. M. An overview of the epidemic of highly pathogenic H5N1 avian influenza virus in Egypt: epidemiology and control challenges. Epidemiol Infect. 2011;139:647–657. doi: 10.1017/S0950268810003122. - DOI - PubMed

[2] Abdelwhab E. M., Hafez H. M. An overview of the epidemic of highly pathogenic H5N1 avian influenza virus in Egypt: epidemiology and control challenges. Epidemiol Infect. 2011;139:647–657. doi: 10.1017/S0950268810003122. - DOI - PubMed

[3] Ayora-Talavera G., Shelton H., Scull M. A., Ren J., Jones I. M., Pickles R. J., Barclay W. S. Mutations in H5N1 influenza virus hemagglutinin that confer binding to human tracheal airway epithelium. PLoS One. 2009;4:e7836. doi: 10.1371/journal.pone.0007836. - DOI - PMC - PubMed

[4] Ayora-Talavera G., Shelton H., Scull M. A., Ren J., Jones I. M., Pickles R. J., Barclay W. S. Mutations in H5N1 influenza virus hemagglutinin that confer binding to human tracheal airway epithelium. PLoS One. 2009;4:e7836. doi: 10.1371/journal.pone.0007836. - DOI - PMC - PubMed

[5] Baskin C. R., Bielefeldt-Ohmann H., Tumpey T. M., Sabourin P. J., Long J. P., Garcia-Sastre A., Tolnay A. E., Albrecht R., Pyles J. A., Olson P. H., Aicher L. D., Rosenzweig E. R., Murali-Krishna K., Clark E. A., Kotur M. S., Fornek J. L., Proll S., Palermo R. E., Sabourin C. L., Katze M. G. Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus. Proc Natl Acad Sci U S A. 2009;106:3455–3460. doi: 10.1073/pnas.0813234106. - DOI - PMC - PubMed

[6] Baskin C. R., Bielefeldt-Ohmann H., Tumpey T. M., Sabourin P. J., Long J. P., Garcia-Sastre A., Tolnay A. E., Albrecht R., Pyles J. A., Olson P. H., Aicher L. D., Rosenzweig E. R., Murali-Krishna K., Clark E. A., Kotur M. S., Fornek J. L., Proll S., Palermo R. E., Sabourin C. L., Katze M. G. Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus. Proc Natl Acad Sci U S A. 2009;106:3455–3460. doi: 10.1073/pnas.0813234106. - DOI - PMC - PubMed

[7] Beigel J. H., Farrar J., Han A. M., Hayden F. G., Hyer R., de Jong M. D., Lochindarat S., Nguyen T. K., Nguyen T. H., Tran T. H., Nicoll A., Touch S., Yuen K. Y., Writing Committee of the World Health Organization Consultation on Human Influenza A H Avian influenza A (H5N1) infection in humans. N Engl J Med. 2005;353:1374–1385. doi: 10.1056/NEJMra052211. - DOI - PubMed

[8] Beigel J. H., Farrar J., Han A. M., Hayden F. G., Hyer R., de Jong M. D., Lochindarat S., Nguyen T. K., Nguyen T. H., Tran T. H., Nicoll A., Touch S., Yuen K. Y., Writing Committee of the World Health Organization Consultation on Human Influenza A H Avian influenza A (H5N1) infection in humans. N Engl J Med. 2005;353:1374–1385. doi: 10.1056/NEJMra052211. - DOI - PubMed

[9] Bel M., Ocana-Macchi M., Liniger M., McCullough K. C., Matrosovich M., Summerfield A. Efficient sensing of avian influenza viruses by porcine plasmacytoid dendritic cells. Viruses. 2011;3:312–330. doi: 10.3390/v3040312. - DOI - PMC - PubMed

[10] Bel M., Ocana-Macchi M., Liniger M., McCullough K. C., Matrosovich M., Summerfield A. Efficient sensing of avian influenza viruses by porcine plasmacytoid dendritic cells. Viruses. 2011;3:312–330. doi: 10.3390/v3040312. - DOI - PMC - PubMed

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An overview of the highly pathogenic H5N1 influenza virus

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An overview of the highly pathogenic H5N1 influenza virus

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