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. 2013 Apr;51(4):1244-6.
doi: 10.1128/JCM.03234-12. Epub 2013 Jan 16.

Evaluation of Epstein-Barr virus, human herpesvirus 6 (HHV-6), and HHV-8 antiviral drug susceptibilities by use of real-time-PCR-based assays

Lotfi Bounaadja  1 , Jocelyne Piret, Nathalie Goyette, Guy Boivin
Affiliations

Evaluation of Epstein-Barr virus, human herpesvirus 6 (HHV-6), and HHV-8 antiviral drug susceptibilities by use of real-time-PCR-based assays

Lotfi Bounaadja et al. J Clin Microbiol. 2013 Apr.

Abstract

Evaluation of candidate antiviral drugs against Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6), and HHV-8 is hampered by the lack of convenient laboratory assays. We developed real-time quantitative PCR assays performed on supernatants of lymphoma cell lines and determined the 50% inhibitory concentrations (IC50s) of nucleoside, nucleotide, and pyrophosphate analogues against these herpesviruses.

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