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. 2012 Oct;3(4):204-8.
doi: 10.4103/0975-9476.104443.

Evaluation of anti-arthritic potential of the methanolic extract of the aerial parts of Costus speciosus

Shruti Srivastava  1 , Pradeep Singh, Keshri K Jha, Garima Mishra, Sourabh Srivastava, Ratan L Khosa
Affiliations

Evaluation of anti-arthritic potential of the methanolic extract of the aerial parts of Costus speciosus

Shruti Srivastava et al. J Ayurveda Integr Med. 2012 Oct.

Abstract

Objective: Costus speciosus Koen. (Keu, Crape ginger), an ornamental plant, widely distributed in India is traditionally used as astringent, aphrodisiac, purgative, anthelmintic, depurative, febrifuge and expectorant. The plant is also used in rheumatism, dropsy, urinary diseases and jaundice. The purpose of this study is to evaluate the anti-arthritic activity of the methanolic extract of the aerial parts of Costus speciosus (CS) in experimental animal models.

Materials and methods: The powdered drug was subjected to successive solvent extraction, with solvents in increasing order of polarity to obtain the methanolic extract of the aerial parts of the plant. CS was evaluated for anti-arthritic action by Freund's adjuvant induced arthritis test in adult Albino rats (150-200 gm). Rats were injected 0.1 ml of complete Freund's adjuvant into the planter region of the left hind paw. Statistical analysis was performed using One way analysis of variance (ANOVA) followed by Bonferonni test. P<0.05 was considered statistically significant.

Results: The methanolic extract of CS in doses of 400 and 800 mg/kg showed 75.50% and 68.33% protection against increase in paw edema, respectively. CS showed dose-dependent action in all the experimental models.

Conclusion: The present study indicates that CS has significant anti-arthritic properties.

Keywords: Arthritis; Costus speciosus; Freund's complete adjuvant; diclofenac sodium; paw volume.

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Conflict of interest statement

Conflict of Interest: None declared.

References

    1. Tripathy S, Sahoo SP, Pradhan D, Sahoo S, Satapathy DK. Evaluation of anti arthritic potential of Hybanthus enneaspermus. Afr J Pharmacy Pharmacol. 2009;3:611–4.
    1. Meera S, Kumar NS, Guptatyam VS. Screening of anti-arthritic, anti-inflammatory and analgesic activity of a polyherbal formulation. Int J Pharmacol. 2008;4:398–402.
    1. Patil RB, Nanjwade BK, Manvi FV. Effect of Sesbania grandiflora and Sesbania sesban Bark on carrageenan induced acute inflammation and adjuvant-induced arthritis in rats. Pharma Sci Monitor: An Int J Pharmaceut Sci. 2010;1:75–89.
    1. Ekambaram S, Perumal SS, Subramanian V. Evaluation of anti-arthritic activity of Strychnos potatorum Linn seeds in Freund′s adjuvant induced arthritic rat model. BMC Complement Altern Med. 2010;10:1–9. - PMC - PubMed
    1. Shah BN, Nayak BS, Seth AK, Jalalpure SS, Patel KN, Patel MA, et al. Search for medicinal plants as a source of anti-inflammatory and anti-arthritic agents - A review. Pharmacog Mag. 2006;2:77–86.

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