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Case Reports
. 2012 Oct;3(4):336-8.
doi: 10.4103/0976-500X.103695.

Toxic epidermal necrolysis due to lamotrigine in a pediatric patient

Manish J Barvaliya  1 , Mahendra K Patel, Tejas K Patel, C B Tripathi
Affiliations
Case Reports

Toxic epidermal necrolysis due to lamotrigine in a pediatric patient

Manish J Barvaliya et al. J Pharmacol Pharmacother. 2012 Oct.

Abstract

A 12-year-male child developed toxic epidermal necrolysis (TEN) probably due to lamotrigine. The patient was on antiepileptic therapy (sodium valproate and clonazepam) since 6-7 months, and lamotrigine was added in the regimen 1-2 months back. A serious cutaneous reaction is more likely to occur during the first 2 months of starting lamotrigine. The use of lamotrigine as an add-on to valproate may have precipitated the reaction. Other drugs were ruled out based on the incubation period of TEN. Drug interactions should be kept in mind with multiple antiepileptic therapies. The patient died because of the severity of reactions and delay in starting the treatment with steroids. One must be vigilant in early detection of the reaction.

Keywords: Cutaneous adverse drug reaction; lamotrigine; toxic epidermal necrolysis.

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Conflict of interest statement

Conflict of Interest: None declared

References

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