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. 2012:2012:437569.
doi: 10.1155/2012/437569. Epub 2012 Dec 27.

New insight into the treatment of advanced differentiated thyroid cancer

Arash Safavi  1 , Aparna Vijayasekaran, Marlon A Guerrero
Affiliations

New insight into the treatment of advanced differentiated thyroid cancer

Arash Safavi et al. J Thyroid Res. 2012.

Abstract

The vast majority of patients with differentiated thyroid cancer (DTC) are treated successfully with surgery and radioactive iodine ablation, yet the treatment of advanced cases is frustrating and largely ineffective. Systemic treatment with conventional cytotoxic chemotherapy is basically ineffective in most patients with advanced DTC. However, a better understanding of the genetics and biologic basis of thyroid cancers has generated opportunities for innovative therapeutic modalities, resulting in several clinical trials. We aim to delineate the latest knowledge regarding the biologic characteristics of DTC and to describe the available data related to novel targeted therapies that have demonstrated clinical effectiveness.

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References

    1. Sherman SI. Thyroid carcinoma. The Lancet. 2003;361(9356):501–511. - PubMed
    1. Agate L, Lorusso L, Elisei R. New and old knowledge on differentiated thyroid cancer epidemiology and risk factors. Journal of Endocrinological Investigation. 2012;35(6):3–9. - PubMed
    1. American Cancer Society. Cancer Facts and Figures 2012. Atlanta, Ga, USA: American Cancer Society; 2012.
    1. Antonelli A, Fallahi P, Ferrari SM, et al. Dedifferentiated thyroid cancer: a therapeutic challenge. Biomedicine and Pharmacotherapy. 2008;62(8):559–563. - PubMed
    1. Tuttle RM. Novel therapeutic options for aggressive thyroid cancer: integrating information from the recent clinical trials into clinical practice. Clinical Thryoidology. 2009;21:3–7.

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