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. 2012:1:72.
doi: 10.4103/2277-9175.102976. Epub 2012 Oct 31.

Clinical evaluation of BIOXTRA in relieving signs and symptoms of dry mouth after head and neck radiotherapy of cancer patients at Seyed-al-Shohada Hospital, Isfahan, Iran

Affiliations

Clinical evaluation of BIOXTRA in relieving signs and symptoms of dry mouth after head and neck radiotherapy of cancer patients at Seyed-al-Shohada Hospital, Isfahan, Iran

Abbas Gookizadeh et al. Adv Biomed Res. 2012.

Abstract

Background: Radiotherapy of head and neck cancers causes acute and chronic xerostomia and acute mucositis. Xerostomia increases risk of radiation caries and affects on oral comfort, fit of prostheses, speech, swallowing, and the growth of caries-producing organisms. Salivary flow rate can be measured by asking patients some questions. There are different types of commercial synthetic saliva such as BIOXTRA, but until now, no one can effectively relieve xerostomia. We tried to design a clinical research on BIOXTRA efficacy for treating xerostomia.

Materials and methods: In this research, 58 patients with head and neck cancer (except salivary gland cancers) treated in Seyed-al-Shohada Hospital. The patients received at least 40-50 GY; and after 2 months of compilation treatment, they were evaluated by asking about having xerostomia. Before and after treatment with the BIOXTRA, the PH of the oral cavity, candida albicans, and lactobacillus counts measured and documented in laboratory. We used BIOXTRA for 2 weeks, 3 times daily, and then re-evaluated patients with some questions.

Results: The counts of candida albicans and lactobacilli statistically significant decreased.

Conclusion: Xerostomia for most patients improved clinically during the day and night while PH of the oral cavity increased.

Keywords: BIOXTRA; radiotherapy; xerostomia.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Frequency of xerostomia before and after treatment

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