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. 2012:1:83.
doi: 10.4103/2277-9175.103005. Epub 2012 Oct 31.

Comparison of intelligence quotient in children surviving leukemia who received different prophylactic central nervous system treatments

Reisi Nahid  1 , Khalilian Leila
Affiliations

Comparison of intelligence quotient in children surviving leukemia who received different prophylactic central nervous system treatments

Reisi Nahid et al. Adv Biomed Res. 2012.

Abstract

Background: Neurocognitive deficits and decrease in intelligence quotient (IQ) is one of the complication of prophylactic central nervous system (CNS) treatment in acute lymphoblastic leukemia (ALL) patients. In this study, we compare the IQ in survivors of ALL that were treated with different prophylactic CNS treatments.

Materials and methods: We compared 43 long-term survivors of ALL: 21 survivors with intrathecal methotrexate (IT MTX) as CNS prophylaxis, 22 with IT MTX+1800-2400 rads cranial irradiation and 20 healthy controls. The IQ was measured using the Raven's test in these patients.

Results: Raven's test revealed significant differences in IQ between the survivors of ALL that were treated with IT MTX, IT MTX plus cranial irradiation and control group. There was no significant difference in the IQ with respect to sex, age and irradiation dose.

Conclusion: We can that reveal that CNS prophylaxis treatment, especially the combined treatment, is associated with IQ score decline in ALL survivors. Therefore,a baseline and an annual assessment of their educational progress are suggested.

Keywords: Acute lymphoblastic leukemia; chemotherapy; intelligence quotient; radiotherapy.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Comparison of the intelligence quotient in three groups
Figure 2
Figure 2
Correlation between the age at diagnosis and intelligence quotient scores
See this image and copyright information in PMC

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