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Review
. 2013 Jan;16(1):43-7.
doi: 10.3779/j.issn.1009-3419.2013.01.08.

[Advanced research of mTOR and lung carcinoid tumors]

[Article in Chinese]
Zixuan Zhang  1 , Mengzhao Wang
Affiliations
Review

[Advanced research of mTOR and lung carcinoid tumors]

[Article in Chinese]
Zixuan Zhang et al. Zhongguo Fei Ai Za Zhi. 2013 Jan.

Abstract
in English, Chinese

Mammalian target of rapamycin (mTOR), a main protein kinase in the phosphoinositide 3-kinase (PI3K)/AKT/mTOR signaling pathway, is an important intracellular mediator involved in multiple celluar functions including proliferation, differentiation, apoptosis, tumorigenesis, and angiogenesis. Recently, the high expression of mTOR and mTOR-related kinase have been found in neuroendocrin tumors. Therefore, mTOR pathway represents an attractive target for new anticancer therapies except surgery.

雷帕霉素靶蛋白（mammalian target of rapamycin, mTOR）作为PI3K/AKT/mTOR路径中主要的蛋白激酶，在胞内调节细胞生长、分化、凋亡以及肿瘤血管生成的信号传导中起重要作用。近年来人们发现mTOR及其相关激酶在神经内分泌肿瘤中表达升高，于是特异性降低mTOR表达的药物成为继手术治疗肺类癌之外的又一选择。

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mTOR信号通路 mTOR signaling pathway
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