Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Jan;16(1):43-7.
doi: 10.3779/j.issn.1009-3419.2013.01.08.

[Advanced research of mTOR and lung carcinoid tumors]

[Article in Chinese]
Zixuan Zhang  1 , Mengzhao Wang
Affiliations
Review

[Advanced research of mTOR and lung carcinoid tumors]

[Article in Chinese]
Zixuan Zhang et al. Zhongguo Fei Ai Za Zhi. 2013 Jan.

Abstract
in English, Chinese

Mammalian target of rapamycin (mTOR), a main protein kinase in the phosphoinositide 3-kinase (PI3K)/AKT/mTOR signaling pathway, is an important intracellular mediator involved in multiple celluar functions including proliferation, differentiation, apoptosis, tumorigenesis, and angiogenesis. Recently, the high expression of mTOR and mTOR-related kinase have been found in neuroendocrin tumors. Therefore, mTOR pathway represents an attractive target for new anticancer therapies except surgery.

雷帕霉素靶蛋白（mammalian target of rapamycin, mTOR）作为PI3K/AKT/mTOR路径中主要的蛋白激酶，在胞内调节细胞生长、分化、凋亡以及肿瘤血管生成的信号传导中起重要作用。近年来人们发现mTOR及其相关激酶在神经内分泌肿瘤中表达升高，于是特异性降低mTOR表达的药物成为继手术治疗肺类癌之外的又一选择。

PubMed Disclaimer

Figures

1
1
mTOR信号通路 mTOR signaling pathway
See this image and copyright information in PMC

References

    1. Yao JC, Hassan M, Phan A, et al. One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35, 825 cases in the United States. J Clin Oncol. 2008;26(18):3063–3072. doi: 10.1200/JCO.2007.15.4377. - DOI - PubMed
    1. Strosberg JR, Nasir A, Hodul P, et al. Biology and treatment of metastatic gastrointestinal neuroendocrine tumors. http://europepmc.org/articles/PMC2633071. Gastrointest Cancer Res. 2008;2(3):113–125. - PMC - PubMed
    1. Harpole DJ, Feldman JM, Buchanan S, et al. Bronchial carcinoid tumors: a retrospective analysis of 126 patients. Ann Thorac Surg. 1992;54(1):50–55. doi: 10.1016/0003-4975(92)91139-Z. - DOI - PubMed
    1. Soga J, Yakuwa Y. Bronchopulmonary carcinoids: An analysis of 1, 875 reported cases with special reference to a comparison between typical carcinoids and atypical varieties. Ann Thorac Cardiovasc Surg. 1999;5(4):211–219. - PubMed
    1. Podsypanina K, Lee RT, Politis C, et al. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. Proc Natl Acad Sci USA. 2001;98(18):10320–10325. doi: 10.1073/pnas.171060098. - DOI - PMC - PubMed

MeSH terms

Substances