doi: 10.1254/jjp.52.493.
Pharmacological activity of angiotensin-II modified by tyrosine sulfation
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- PMID: 2332941
- DOI: 10.1254/jjp.52.493
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Pharmacological activity of angiotensin-II modified by tyrosine sulfation
Jpn J Pharmacol.
1990 Mar.
Free article
Abstract
An angiotensin-II analogue with a sulfated tyrosine residue was prepared by arylsulfotransferase treatment of synthetic human angiotensin-II. Its biological activities were studied in isolated smooth muscles, and its effect on blood pressure was determined. The sulfated angiotensin-II (AII-S) was about 15-30 fold less potent than angiotensin-II (AII) for ileum contraction and gallbladder contraction. The hypertensive potency of AII-S was about 30-fold less than that of AII.
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