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. 1990 Mar;52(3):493-5.
doi: 10.1254/jjp.52.493.

Pharmacological activity of angiotensin-II modified by tyrosine sulfation

M Hagiwara  1 , E Ohuchi, K Hongo, M Oki, K Wada, T Morikawa, K Kobashi
Affiliations
Free article

Pharmacological activity of angiotensin-II modified by tyrosine sulfation

M Hagiwara et al. Jpn J Pharmacol. 1990 Mar.
Free article

Abstract

An angiotensin-II analogue with a sulfated tyrosine residue was prepared by arylsulfotransferase treatment of synthetic human angiotensin-II. Its biological activities were studied in isolated smooth muscles, and its effect on blood pressure was determined. The sulfated angiotensin-II (AII-S) was about 15-30 fold less potent than angiotensin-II (AII) for ileum contraction and gallbladder contraction. The hypertensive potency of AII-S was about 30-fold less than that of AII.

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