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Editorial
. 2013 Jan 18;112(2):224-6.
doi: 10.1161/CIRCRESAHA.112.300494.

Membrane receptor neighborhoods: snuggling up to the nucleus

Donald M Bers
Editorial

Membrane receptor neighborhoods: snuggling up to the nucleus

Donald M Bers. Circ Res. .
No abstract available

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Figures

Figure 1
Figure 1. Three models of membrane receptor signaling to InsP3 dependent Ca2+ signals
A) in the traditional model receptors (as for ET-1 in this example) activate InsP3 production at the cell periphery (or throughout the plasma membrane). But the InsP3 must diffuse a potentially long way to the nuclear InsP3R to cause local nuclear [Ca2+] elevation by release from the Ca2+ store in the nuclear envelope. B) The model shown by Ibarra et al. indicating the IGF-1R complex in plasma membrane invaginations, reducing the diffusional distance for InsP3 to reach the nucleus. C) A third model where functional G-protein coupled receptors can exist near or on the nuclear envelope. RyR, ryanodine receptor, ICa, Ca current, ATP, SR/ER Ca-ATPase; MF, myofilaments; P, phosphorylation, Cam, calmodulin, Gx, G-protein, DAG, diacylglycerol.
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References

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