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Review
. 2013;10(2):171-5.
doi: 10.7150/ijms.5312. Epub 2013 Jan 5.

Biodegradable conduit small gap tubulization for peripheral nerve mutilation: a substitute for traditional epineurial neurorrhaphy

Peixun Zhang  1 , Na Han, Tianbing Wang, Feng Xue, Yuhui Kou, Yanhua Wang, Xiaofeng Yin, Laijin Lu, Guanglei Tian, Xu Gong, Shanlin Chen, Yu Dang, Jianping Peng, Baoguo Jiang
Affiliations
Review

Biodegradable conduit small gap tubulization for peripheral nerve mutilation: a substitute for traditional epineurial neurorrhaphy

Peixun Zhang et al. Int J Med Sci. 2013.

Abstract

Nerve regeneration and re-innervation are usually difficult after peripheral nerve injury. Epineurium neurorrhaphy to recover the nerve continuity is the traditional choice of peripheral nerve mutilation without nerve defects, whereas the functional recovery remains quite unsatisfactory. Based on previous research in SD rats and Rhesus Monkeys, a multiple centers clinical trial about biodegradable conduit small gap tubulization for peripheral nerve mutilation to substitute traditional epineurial neurorrhaphy was carried out. Herein, the authors reviewed the literature that focused on peripheral nerve injury and possible clinical application, and confirmed the clinical possibilities of biodegradable conduit small gap tubulization to substitute traditional epineurial neurorrhaphy for peripheral nerve mutilation. The biodegradable conduit small gap tubulization to substitute traditional epineurial neurorrhaphy for peripheral nerve mutilation may be a revolutionary innovation in peripheral nerve injury and repair field.

Keywords: Biodegradable Conduit; Epineurial Neurorrhaphy; Peripheral Nerve Mutilation; Small Gap; Tubulization.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
The conduit small gap tubulization methods used in experimental group. The number 1,2,3,4 was the suture needling sequence. When finished, there was 2mm small gap remained between the two ruptured stumps.
Figure 2
Figure 2
The biodegradable conduit small gap tubulization methods. This picture was taken from a patient who was diagnosed as right wrist totally ruptured median nerve and accepted the biodegradable conduit small gap tubulization methods to repair median nerve during operation. A. The ruptured median nerve stumps; B, the biodegradable conduit small gap tubulization.
See this image and copyright information in PMC

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