A clinicopathologic study of esophageal 860 benign and malignant lesions in 910 cases of consecutive esophageal biopsies

Abstract

The author reviewed 910 cases of consecutive esophageal biopsies in the last 15 year in the pathology laboratory of our hospital. There were 693 normal mucosa and benign lesions (76.2%) and 217 malignant lesions (23.8%). No significant changes were recognized in the esophagus in 50 biopsies (5.5%). In benign lesions, the number and frequency (percentages) were as follows: 263 chronic esophagitis (28.9%), 98 heterotopic gastric mucosa (10.8%), 3 heterotopic colonic mucosa (0.3%), 71 glycogenic acanthosis (7.8%), 68 candidiasis (7.5%), 35 benign ulcer (3.8%), 41 squamous papilloma (4.5%), 4 granular cell tumor (0.4%), 1 tubular adenoma (0.1%), 2 cytomegalovirus esophagitis (0.2%), 3 leiomyoma (0.3%), 17 basal cell hyperplasia (1.9%), and 37 Barrett's epithelium (4%). In malignant lesions, the number and frequency (percentages) were as follows: 53 mild dysplasia (5.8%), 29 moderate dysplasia (3.2%), 31 severe dysplasia (3.4%), 13 carcinoma in situ (1.4%), 68 squamous cell carcinoma (7.5%), 7 primary adenocarcinoma (0.8%), 1 primary signet ring cell carcinoma (0.1%), 4 primary small cell carcinoma (0.4%), 2 primary amelanotic malignant melanoma (0.2%), 1 primary undifferentiated sarcoma (0.1%), 7 gastric cancer invasion (0.8%), and 1 primary adenoid cystic carcinoma (0.1%). In this article, the clinicopathologic features of these esophageal lesions were described.

Keywords: Esophagus; benign lesions; clinicopathologies; immunohistochemistry; malignant lesions.

Figure 1

Heterotopic gastric mcuosa in the esophagus. Fundic glands are seen. HE, x100.

Figure 2

Heterotopic colonic mucosa in the esophagus.Goblet cells are seen. HE, x200.

Figure 3

Sqaumous papilloma of the esophagus. HE, x20.

Figure 4

Granular cell tumor of the esophagus. HE,x200.

Figure 5

Mild dysplasia of the esophagus, HE, x100.

Figure 6

Moderate dysplasia of the esophagus. HE,x100.

Figure 7

Severe dysplasia of the esophagus. HE,x100.

Figure 8

Carcinoma in situ of the esophagus. HE,x100.

Figure 9

Squamous cell carcinoma of the esophagus. HE, x100.

Figure 10

Ordinary adenocarcinoma of the esophagus.HE, x200.

Figure 11

Signet ring cell carcinoma of the esophagus.HE, x200.

Figure 12

Small cell carcinoma of the esophagus. HE, x200.

Figure 13

A: Amelanotic melanoma of the esophagus. HE, x200. B: Melanosome (HMB45) is positive in melanomaof A. x200.

Figure 14

Adenoid cystic carcinoma of the esophagus.HE, x100.