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Practice Guideline
. 2013 Feb;61(2):225-43.
doi: 10.1016/j.annemergmed.2012.11.005.

Clinical Policy: Use of intravenous tPA for the management of acute ischemic stroke in the emergency department

American College of Emergency Physicians; American Academy of Neurology
Collaborators
Practice Guideline

Clinical Policy: Use of intravenous tPA for the management of acute ischemic stroke in the emergency department

American College of Emergency Physicians et al. Ann Emerg Med. 2013 Feb.

Abstract

This policy was developed by a joint writing panel of the American College of Emergency Physicians and the American Academy of Neurology. The panel reviewed the literature to derive evidence-based recommendations to help clinicians answer the following critical questions: (1) Is intravenous tissue plasminogen activator (tPA) safe and effective for acute ischemic stroke patients if given within 3 hours of symptom onset? (2) Is intravenous tPA safe and effective for acute ischemic stroke patients treated between 3 to 4.5 hours after symptom onset? Evidence was graded and recommendations were given based on the strength of the available data in the medical literature.

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Comment in

  • The lytic lottery.
    Ellison D. Ellison D. Ann Emerg Med. 2013 Oct;62(4):432-3. doi: 10.1016/j.annemergmed.2013.03.038. Ann Emerg Med. 2013. PMID: 24054099 No abstract available.
  • In reply.
    Edlow JA, Smith EE. Edlow JA, et al. Ann Emerg Med. 2013 Oct;62(4):433. doi: 10.1016/j.annemergmed.2013.04.015. Ann Emerg Med. 2013. PMID: 24054100 No abstract available.

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