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Review
. 2013 Apr;37(4):392-5.
doi: 10.1016/j.leukres.2012.12.016. Epub 2013 Jan 16.

Mortality in hypereosinophilic syndrome: 19 years of experience at Mayo Clinic with a review of the literature

Jenna C Podjasek  1 , Joseph H Butterfield
Affiliations
Review

Mortality in hypereosinophilic syndrome: 19 years of experience at Mayo Clinic with a review of the literature

Jenna C Podjasek et al. Leuk Res. 2013 Apr.

Abstract

Background: Information in the literature regarding causes of mortality in patients with hypereosinophilic syndrome (HES) is limited.

Methods: This was a retrospective review of the morbidities and causes of death in HES patients at Mayo Clinic.

Results: Overall, out of the 247 diagnosed HES patients, 23 died during the 19 years that this review encompassed. The cause of death was identified in 15 patients (65%): cardiac dysfunction in 5 (33%), infection in 3 (20%), unrelated malignancy in 3 (20%), thromboembolic phenomena in 2 (13%), and vascular disease in 2 (13%).

Conclusion: Targeted monitoring of the at-risk end organs, combined with early treatment, may have the ability to improve survival and reduce morbidity in HES patients.

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