Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 Mar;154(3):326-327.
doi: 10.1016/j.pain.2012.12.012. Epub 2012 Dec 28.

N-acylethanolamine acid amidase (NAAA), a new path to unleash PPAR-mediated analgesia

Bradley K Taylor  1
Affiliations
Comment

N-acylethanolamine acid amidase (NAAA), a new path to unleash PPAR-mediated analgesia

Bradley K Taylor. Pain. 2013 Mar.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author has no conflicts of interest

Figures

Figure 1
Figure 1
Proposed mechanism of pain inhibition by N-acylethanolamine acid amidase (NAAA). Panel A: key enzymatic pathways for fatty acid ethanolamide synthesis and degradation (solid black arrows), and a proposed mechanism of pain inhibition involving palmitoylethanolamide (PEA) activation of PPARα (blue arrows), and PPARα-mediated pain inhibition (green arrows). Panel B: Injury-induced inhibition of the enzyme that synthesizes PEA (N-acyl-phosphatidylethanolamine phospholipase D, NAPE-PLD) and ensuing loss of PEA-PPARα antihyperalgesia. Panel C: Inhibition of N-acylethanolamine acid amidase (NAAA) with the novel compound ARN077 raises PEA concentrations, thus reinstating PPARα antihyperalgesia. PE, phosphatidylethanolamine. PC, phosphatidylcholine. NAT, N-acetyltransferase. NAPE, N-acylphosphatidylethanolamines. AEA, arachidonoylethanolamide (anandamide). OEA, oleoylethanolamide. AA, arachidonic acid. OA, oleic acid. PA, palmitic acid. EA, ethanolamine.
See this image and copyright information in PMC

Comment on

References

    1. Churi SB, Abdel-Aleem OS, Tumber KK, Scuderi-Porter H, Taylor BK. Intrathecal rosiglitazone acts at peroxisome proliferator-activated receptor-gamma to rapidly inhibit neuropathic pain in rats. J Pain. 2008;9(7):639–649. - PMC - PubMed
    1. Di Marzo V. Inhibitors of endocannabinoid breakdown for pain: not so FA(AH)cile, after all. Pain. 2012;153(9):1785–1786. - PubMed
    1. Duranti A, Tontini A, Antonietti F, Vacondio F, Fioni A, Silva C, Lodola A, Rivara S, Solorzano C, Piomelli D, Tarzia G, Mor M. N-(2-oxo-3-oxetanyl)carbamic acid esters as N-acylethanolamine acid amidase inhibitors: synthesis and structure-activity and structure-property relationships. Journal of medicinal chemistry. 2012;55(10):4824–4836. - PubMed
    1. Fehrenbacher JC, Loverme J, Clarke W, Hargreaves KM, Piomelli D, Taylor BK. Rapid pain modulation with nuclear receptor ligands. Brain Res Rev. 2009;60(1):114–124. - PMC - PubMed
    1. Khasabova IA, Xiong Y, Coicou LG, Piomelli D, Seybold V. Peroxisome proliferator-activated receptor alpha mediates acute effects of palmitoylethanolamide on sensory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012;32(37):12735–12743. - PMC - PubMed