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Comment
. 2013 Feb;9(2):69-70.
doi: 10.1038/nchembio.1161.

Redox control: A black hole for oxidized glutathione

Jakob R Winther, Ursula Jakob
Comment

Redox control: A black hole for oxidized glutathione

Jakob R Winther et al. Nat Chem Biol. 2013 Feb.

Abstract

There is a considerable amount of oxidized glutathione in living cells, yet it is virtually absent from the cytosol. The mystery of where it resides has now been solved. A study in baker’s yeast revealed that oxidized glutathione is selectively stashed in vacuoles.

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Figures

Figure 1
Figure 1
A new star in redox homeostasis. In the cytosol, a high ratio between reduced (GSH) and oxidized (GSSG) glutathione is maintained by the enzyme glutaredoxin reductase (Glr1). In a competing reaction for GSSG removal, the membrane transporter YCF1 sweeps up GSSG for vacuolar sequestration.
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References

    1. Morgan B, et al. Nat. Chem. Biol. 2013;9:119–125. - PubMed
    1. Hwang C, Sinskey AJ, Lodish HF. Science. 1992;257:1496–1502. - PubMed
    1. Østergaard H, Tachibana C, Winther JR. J. Cell Biol. 2004;166:337–345. - PMC - PubMed
    1. Lazard M, et al. FEBS J. 2011;278:4112–4121. - PubMed
    1. Dooley CT, et al. J. Biol. Chem. 2004;279:22284–22293. - PubMed

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