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. 2013 Apr;73(5):542-8.
doi: 10.1002/pros.22594. Epub 2013 Jan 17.

The G84E mutation in the HOXB13 gene is associated with an increased risk of prostate cancer in Poland

Wojciech Kluźniak  1 , Dominika Wokołorczyk, Aniruddh Kashyap, Anna Jakubowska, Jacek Gronwald, Tomasz Huzarski, Tomasz Byrski, Tadeusz Dębniak, Adam Gołąb, Bartłomiej Gliniewicz, Andrzej Sikorski, Jerzy Switała, Tomasz Borkowski, Andrzej Borkowski, Andrzej Antczak, Lukasz Wojnar, Jacek Przybyła, Marek Sosnowski, Bartosz Małkiewicz, Romuald Zdrojowy, Paulina Sikorska-Radek, Józef Matych, Jacek Wilkosz, Waldemar Różański, Jacek Kiś, Krzysztof Bar, Piotr Bryniarski, Andrzej Paradysz, Konrad Jersak, Jerzy Niemirowicz, Piotr Słupski, Piotr Jarzemski, Michał Skrzypczyk, Jakub Dobruch, Paweł Domagała, Mohammad R Akbari, Jan Lubiński, Steven A Narod, Cezary Cybulski; Polish Hereditary Prostate Cancer Consortium
Affiliations

The G84E mutation in the HOXB13 gene is associated with an increased risk of prostate cancer in Poland

Wojciech Kluźniak et al. Prostate. 2013 Apr.

Abstract

Background: The G84E mutation in the HOXB13 gene has been associated with a high lifetime risk of prostate cancer in North America (about 20-fold). The geographical and ethnic extent of this recurrent allele has not yet been determined.

Methods: We assayed for the presence of the G84E mutation in 3,515 prostate cancer patients and 2,604 controls from Poland and estimated the odds ratio for prostate cancer associated with the allele.

Results: The G84E mutation was detected in 3 of 2,604 (0.1%) individuals from the general population in Poland and in 20 of 3,515 (0.6%) men with prostate cancer (Odds ratio [OR] = 5.0; 95% CI: 1.5-16.7; P = 0.008). The allele was present in 4 of 416 (1.0%) men with familial prostate cancer (OR = 8.4, 95% CI: 1.9-37.7; P = 0.005).

Conclusions: The G84E mutation predisposes to prostate cancer in Poland, but accounts for only a small proportion of cases. We expect that the G84E founder mutation might be present in other Slavic populations.

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