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. 2013:105:185-99.
doi: 10.1093/bmb/lds038. Epub 2013 Jan 20.

Epidemiology and burden of osteoarthritis

Anna Litwic  1 , Mark H Edwards, Elaine M Dennison, Cyrus Cooper
Affiliations

Epidemiology and burden of osteoarthritis

Anna Litwic et al. Br Med Bull. 2013.

Abstract

Background: Osteoarthritis (OA) is a degenerative joint disease involving the cartilage and many of its surrounding tissues. Disease progression is usually slow but can ultimately lead to joint failure with pain and disability. OA of the hips and knees tends to cause the greatest burden to the population as pain and stiffness in these large weight-bearing joints often leads to significant disability requiring surgical intervention.

Sources of data: The article reviews the existing data on epidemiology of osteoarthritis and the burden of the disease.

Areas of agreement: Symptoms and radiographic changes are poorly correlated in OA. Established risk factors include obesity, local trauma and occupation. The burden of OA is physical, psychological and socioeconomic.

Areas of controversy: Available data does not allow definite conclusion regarding the roles of nutrition, smoking and sarcopenia as risk factors for developing OA.

Growing points: Variable methods of diagnosing osteoarthritis have significantly influenced the comparability of the available literature.

Areas timely for developing research: Further research is required to fully understand how OA affects an individual physically and psychologically, and to determine their healthcare need.

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Figures

Figure 1
Figure 1
Prevalence of radiographic osteoarthritis of the hand, hip and knee (4)
Figure 2
Figure 2
Incidence of clinical osteoarthritis of the hand, knee and hip (5)
Figure 3
Figure 3
Long-term progression of radiographic knee osteoarthritis (from: Leyland KM, Hart D, Javaid MK, Judge A, Kiran A, Soni A, Goulston LM, Cooper C, Spector TD, Arden NK. The natural history of radiographic knee osteoarthritis: A fourteen year population-based cohort study. Arthritis Rheum . 2012 Mar 15. doi: 10.1002/art.34415. [Epub ahead of print])
Figure 4
Figure 4
Age and sex-specific incidence rates of total knee arthroplasty (34)
See this image and copyright information in PMC

References

    1. Hutton CW. Osteoarthritis: the cause not result of joint failure? Annals of the Rheumatic Diseases. 1989;48(11):958–961. - PMC - PubMed
    1. Kellgren J, Lawrence J. Atlas of standard radiographs. The epidemiology of chronic rheumatism. Vol. 2. Blackwell Scientific Publications; Oxford: 1963.
    1. Altman R, Alarcon G, Appelrouth D, Bloch D, Borenstein D, Brandt K, et al. The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip. Arthritis Rheum. 1991;34:505–14. - PubMed
    1. Altman R, Asch E, Bloch D, Bole D, Borenstein K, Brandt K, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Arthritis Rheum. 1986;29:1039–49. - PubMed
    1. Altman R, Alarcon G, Appelrouth D, Bloch D, Borenstein K, Brandt K, et al. The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand. Arthritis Rheum. 1990;33:1601–10. - PubMed

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