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. 2012 Dec;44(4):267-70.
doi: 10.4143/crt.2012.44.4.267. Epub 2012 Dec 31.

A case of locally advanced breast cancer complicated by pulmonary tumor thrombotic microangiopathy

Hak Jin Kim  1 , Mi Hyang Kwak, Sun-Young Kong, Moon-Woo Seong, Han-Sung Kang, Keun Seok Lee, Jungsil Ro
Affiliations

A case of locally advanced breast cancer complicated by pulmonary tumor thrombotic microangiopathy

Hak Jin Kim et al. Cancer Res Treat. 2012 Dec.

Abstract

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare, malignancy-related complication that causes marked pulmonary hypertension, right heart failure, and death. We report on a patient with locally advanced breast cancer whose course was complicated by fatal PTTM based on clinical and laboratory findings.

Keywords: Breast neoplasms; Pulmonary hypertension; Pulmonary tumor thrombotic microangiopathy.

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Conflict of interest statement

Conflicts of interest relevant to this article was not reported.

Figures

Fig. 1
Fig. 1
Peripheral blood smear showing schistocytes and reticulocytes (×400).
Fig. 2
Fig. 2
Chest computed tomography image shows an enhanced mass in the right breast and dilatation of the pulmonary artery. There was no evidence of thromboembolism in either the pulmonary artery or segmental artery.
Fig. 3
Fig. 3
Echocardiogram showing right ventricular enlargement and a D-shaped left ventricle.
Fig. 4
Fig. 4
Lung perfusion scan showing multiple wedge-shaped perfusion defects in both lungs. RT-LAT, right lateral; RPO, right posterior oblique; LT-LAT, left lateral; LPO, left posterior oblique.
See this image and copyright information in PMC

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