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Case Reports
. 2012 Sep;4(3):275-80.
doi: 10.1159/000346284. Epub 2012 Dec 20.

Treatment of severe cold contact urticaria with omalizumab: case reports

Petra Brodská  1 , Peter Schmid-Grendelmeier
Affiliations
Case Reports

Treatment of severe cold contact urticaria with omalizumab: case reports

Petra Brodská et al. Case Rep Dermatol. 2012 Sep.

Abstract

We report 2 patients with cold urticaria with different response to treatment with omalizumab (Xolair(®)). Cold contact urticaria (CCU) is a common subtype of physical urticaria. It is characterized by the development of wheal and/or angioedema within minutes after cold contact. Clinical manifestation of CCU can range from mild, localized whealing to life-threatening anaphylactic shock reactions. Omalizumab has been described to be useful in cases of chronic urticaria and may be an interesting option for treatment of CCU. We describe one patient with significant and long-lasting improvement of symptoms and one without any improvement after anti-immunoglobulin E therapy. In our case reports, we want to highlight that there is still a small group of patients without benefit from omalizumab treatment. It is necessary to identify this minor subgroup of patients where omalizumab does not represent an effective treatment possibility.

Keywords: Anti-immunoglobulin E; Cold contact urticaria; Omalizumab; Physical urticaria.

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