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. 2012 Dec;9(4):401-7.
doi: 10.3724/SP.J.1263.2011.12282.

High density lipoproteins and atherosclerosis: emerging aspects

Federica Sala  1 , Alberico Luigi Catapano, Giuseppe Danilo Norata
Affiliations

High density lipoproteins and atherosclerosis: emerging aspects

Federica Sala et al. J Geriatr Cardiol. 2012 Dec.

Abstract

High density lipoproteins (HDL) promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. This ability is responsible for the most relevant anti-atherogenic effect of HDL. The ability of HDL to promote cholesterol efflux results also in the modulation of a series of responses in the immune cells involved in atherosclerosis, including monocyte-macrophages, B and T lymphocytes. Furthermore, during inflammation, the composition of this class of lipoproteins varies to a large extent, thus promoting the formation of dysfunctional HDL. The aim of this review is to discuss the emerging role of HDL in modulating the activity of immune cells and immune-inflammatory mediators during atherogenesis.

Keywords: Apolipoprotein; High density lipoproteins; Immune response; Sphingosine-1-phosphate.

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