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Comparative Study
. 2012 Dec;10(12):2648-60.
doi: 10.3390/md10122648.

Adjuvant activity of Sargassum pallidum polysaccharides against combined Newcastle disease, infectious bronchitis and avian influenza inactivated vaccines

Li-Jie Li  1 , Ming-Yi Li, Yan-Tuan Li, Jing-Jing Feng, Feng-Qiang Hao, Zhang Lun
Affiliations
Comparative Study

Adjuvant activity of Sargassum pallidum polysaccharides against combined Newcastle disease, infectious bronchitis and avian influenza inactivated vaccines

Li-Jie Li et al. Mar Drugs. 2012 Dec.

Abstract

This study evaluates the effects of Sargassum pallidum polysaccharides (SPP) on the immune responses in a chicken model. The adjuvanticity of Sargassum pallidum polysaccharides in Newcastle disease (ND), infectious bronchitis (IB) and avian influenza (AI) was investigated by examining the antibody titers and lymphocyte proliferation following immunization in chickens. The chickens were administrated combined ND, IB and AI inactivated vaccines containing SPP at 10, 30 and 50 mg/mL, using an oil adjuvant vaccine as a control. The ND, IB and AI antibody titers and the lymphocyte proliferation were enhanced at 30 mg/mL SPP. In conclusion, an appropriate dose of SPP may be a safe and efficacious immune stimulator candidate that is suitable for vaccines to produce early and persistent prophylaxis.

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Figures

Figure 1
Figure 1
Changes in ND-HI antibody in each group in the immune response (log 2).
Figure 2
Figure 2
Changes in IB-HI antibody in each group in the immune response (log 2).
Figure 3
Figure 3
Changes in AI-HI antibody in each group in the immune response (log 2).
See this image and copyright information in PMC

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