The ataxic cirrhotic
- PMID: 23342419
- PMCID: PMC5922606
- DOI: 10.7861/clinmedicine.12-6-598
The ataxic cirrhotic
Abstract
Hepatic cirrhosis secondary to excess alcohol consumption is increasing in incidence, and these patients can develop ataxia secondary to direct toxic effects of alcohol on the cerebellum. However, it is important to remain vigilant for other causes of an unsteady gait, including space-occupying lesions and medications, such as phenytoin. Patients with hypoalbuminaemia, such as those with cirrhosis, are more prone to developing toxic effects from phenytoin, as this Lesson describes. Therefore, dose adjustments might be necessary.
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References
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- Miller CA. Toxicity, Phenytoin. http://emedicine.medscape.com/article/816447-overview#a0101 [Accessed 2 October 2012].
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- Fleming KM. Aithal GP. Solaymani-Dodaran M, et al. Incidence and prevalence of cirrhosis in the United Kingdom, 1992–2001: a general population-based study. J Hepatol. 2008;49:732–8. - PubMed
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- Dager WE. Inciardi JF. Howe TL. Estimating phenytoin concentrations by the Sheiner-Tozer method in adults with pronounced hypoalbuminaemia. Ann Pharmacother. 1995;29:667–70. - PubMed
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