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. 2013 Jan 17;5(1):223-33.
doi: 10.3390/nu5010223.

Effects of collagen and collagen hydrolysate from jellyfish umbrella on histological and immunity changes of mice photoaging

Jian Fan  1 , Yongliang Zhuang, Bafang Li
Affiliations

Effects of collagen and collagen hydrolysate from jellyfish umbrella on histological and immunity changes of mice photoaging

Jian Fan et al. Nutrients. .

Abstract

Jellyfish collagen (JC) was extracted from jellyfish umbrella and hydrolyzed to prepare jellyfish collagen hydrolysate (JCH). The effects of JC and JCH on UV-induced skin damage of mice were evaluated by the skin moisture, microscopic analyses of skin and immunity indexes. The skin moisture analyses showed that moisture retention ability of UV-induced mice skin was increased by JC and JCH. Further histological analysis showed that JC and JCH could repair the endogenous collagen and elastin protein fibers, and could maintain the natural ratio of type I to type III collagen. The immunity indexes showed that JC and JCH play a role in enhancing immunity of photoaging mice in vivo. JCH showed much higher protective ability than JC. These results suggest that JCH as a potential novel antiphotoaging agent from natural resources.

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Figures

Figure 1
Figure 1
The effect of JC and JCH on morphology of photoaging skin (magnification 200×).
Figure 2
Figure 2
The effect of JC and JCH on endogenous collagen of photoaging skin (magnification 200×); Red: collagen (formula image).
Figure 3
Figure 3
The effect of JC and JCH on collagen type I and collagen type III of photoaging skin (magnification 200×); Yellow-orange: collagen type I (formula image), green: collagen type III (formula image).
Figure 4
Figure 4
The effects of JC and JCH on elastin protein fiber of photoaging skin (magnification 200×); Blue-black to black: elastic fibres (formula image).
See this image and copyright information in PMC

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