Synthesis of some 1,4-dihydropyridine derivatives and their calcium antagonistic activity
Affiliations
- PMID: 2334450
Item in Clipboard
Synthesis of some 1,4-dihydropyridine derivatives and their calcium antagonistic activity
Arzneimittelforschung.
1990 Feb.
Abstract
Seven new 2,6-dimethyl-3,5-diacetyl-4-aryl-1,4-dihydropyridine derivatives have been prepared. Their structures have been elucidated by UV, IR, 1H-NMR and elementary analysis. The calcium antagonistic activity of these compounds were tested in K(+)-depolarized taenia coli precontracted with 1 mmol/l Ca2+.
Similar articles
-
Synthesis of some 1,4,5,6,7,8-hexahydroquinoline derivatives and their calcium antagonistic activity.Arzneimittelforschung. 1993 Oct;43(10):1052-5. Arzneimittelforschung. 1993. PMID: 8267668
-
3-Acetyl-4-aryl-5-oxo-2,7,7-trimethyl-1,4,5,6,7,8-hexahydro-quinoline derivatives and their calcium antagonistic activities.Arzneimittelforschung. 1995 Nov;45(11):1154-6. Arzneimittelforschung. 1995. PMID: 8929229
-
Synthesis, QSAR and calcium channel antagonist activity of new 1,4-dihydropyridine derivatives containing 1-methyl-4,5-dichloroimidazolyl substituents.Arch Pharm (Weinheim). 2007 Oct;340(10):549-56. doi: 10.1002/ardp.200600211. Arch Pharm (Weinheim). 2007. PMID: 17849444
-
The 1,4-dihydropyridine receptor: a regulatory component of the Ca2+ channel.J Cardiovasc Pharmacol. 1984;6 Suppl 7:S949-55. J Cardiovasc Pharmacol. 1984. PMID: 6085383 Review.
-
1,4-Dihydropyridines--a basis for developing new drugs.Med Res Rev. 1989 Jul-Sep;9(3):291-324. doi: 10.1002/med.2610090304. Med Res Rev. 1989. PMID: 2666803 Review. No abstract available.
Cited by
-
3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7) as a new multidrug resistance reverting agent devoid of effects on vascular smooth muscle contractility.Br J Pharmacol. 2004 Feb;141(3):415-22. doi: 10.1038/sj.bjp.0705635. Epub 2004 Jan 12. Br J Pharmacol. 2004. PMID: 14718255 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Miscellaneous