The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test
- PMID: 23344554
- DOI: 10.1007/s00213-013-2969-0
The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test
Abstract
Rationale: Lithium has been a standard pharmacological treatment for bipolar disorder over the last 60 years; however, the molecular targets through which lithium exerts its therapeutic effects are still not defined. Attenuation of the phosphatidylinositol signal transduction pathway as a consequence of inhibition of inositol monophosphatase (IMPase) has been proposed as one of the possible mechanisms for lithium-induced mood stabilization.
Objectives: The objective was to study the behavioral effect of the specific competitive IMPase inhibitor L-690,330 in mice in the lithium-sensitive pilocarpine-induced seizures paradigm and the forced swim test (FST).
Methods: The inhibitor was administered intracerebroventricularly in liposomes.
Results: L-690,330 increased the sensitivity to subconvulsive doses of pilocarpine and decreased immobility time in the FST.
Conclusions: It is possible that the behavioral effects of lithium in the pilocarpine-induced seizures and in the FST are mediated through the inhibition of IMPase, but reversal of the inhibitor's effect with intracerebroventricular inositol would be an important further step in proof.
Similar articles
-
Effects of the putative lithium mimetic ebselen on pilocarpine-induced neural activity.Eur J Pharmacol. 2020 Sep 15;883:173377. doi: 10.1016/j.ejphar.2020.173377. Epub 2020 Jul 18. Eur J Pharmacol. 2020. PMID: 32687920
-
Inositol-deficient food augments a behavioral effect of long-term lithium treatment mediated by inositol monophosphatase inhibition: an animal model with relevance for bipolar disorder.J Clin Psychopharmacol. 2015 Apr;35(2):175-7. doi: 10.1097/JCP.0000000000000284. J Clin Psychopharmacol. 2015. PMID: 25679134
-
IMPA1 is essential for embryonic development and lithium-like pilocarpine sensitivity.Neuropsychopharmacology. 2008 Feb;33(3):674-84. doi: 10.1038/sj.npp.1301431. Epub 2007 Apr 25. Neuropsychopharmacology. 2008. PMID: 17460611
-
Ziskind-Somerfeld Research Award 1993. Biochemical, behavioral, and clinical studies of the role of inositol in lithium treatment and depression.Biol Psychiatry. 1993 Dec 15;34(12):839-52. doi: 10.1016/0006-3223(93)90052-f. Biol Psychiatry. 1993. PMID: 8110911 Review.
-
Inositol monophosphatase--a putative target for Li+ in the treatment of bipolar disorder.Trends Neurosci. 1995 Aug;18(8):343-9. doi: 10.1016/0166-2236(95)93926-o. Trends Neurosci. 1995. PMID: 7482796 Review.
Cited by
-
Intrathecal drug delivery in the era of nanomedicine.Adv Drug Deliv Rev. 2020;165-166:77-95. doi: 10.1016/j.addr.2020.02.006. Epub 2020 Mar 3. Adv Drug Deliv Rev. 2020. PMID: 32142739 Free PMC article.
-
Ebselen has lithium-like effects on central 5-HT2A receptor function.Br J Pharmacol. 2018 Jul;175(13):2599-2610. doi: 10.1111/bph.14179. Epub 2018 May 22. Br J Pharmacol. 2018. PMID: 29488218 Free PMC article.
-
Advances in Intrathecal Nanoparticle Delivery: Targeting the Blood-Cerebrospinal Fluid Barrier for Enhanced CNS Drug Delivery.Pharmaceuticals (Basel). 2024 Aug 15;17(8):1070. doi: 10.3390/ph17081070. Pharmaceuticals (Basel). 2024. PMID: 39204177 Free PMC article. Review.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous