Virus-mediated Genetic Surgery: Homologous Recombination With a Little "Helper" From My Friends

Affiliations

¹ 1] Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, California, USA [2] Department of Laboratory Medicine, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Helen Diller Family Comprehensive Cancer Center, Institute for Human Genetics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.

Dieter C Gruenert et al. Mol Ther Nucleic Acids. 2012.

. 2012 Jan 24;1(1):e2.

doi: 10.1038/mtna.2011.7.

¹ 1] Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, California, USA [2] Department of Laboratory Medicine, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Helen Diller Family Comprehensive Cancer Center, Institute for Human Genetics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.

No abstract available

References

1. Capecchi MR. Altering the genome by homologous recombination. Science. 1989;244:1288–1292. - PubMed
1. Gruenert DC, Bruscia E, Novelli G, Colosimo A, Dallapiccola B, Sangiuolo F.et al. (2003Sequence-specific modification of genomic DNA by small DNA fragments J Clin Invest 112637–641. - PMC - PubMed
1. Smithies O, Gregg RG, Boggs SS, Koralewski MA., and, Kucherlapati RS. Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination. Nature. 1985;317:230–234. - PubMed
1. Thomas KR., and, Capecchi MR. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell. 1987;51:503–512. - PubMed
1. Carroll D. Progress and prospects: zinc-finger nucleases as gene therapy agents. Gene Ther. 2008;15:1463–1468. - PMC - PubMed