Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Apr;51(4):1256-9.
doi: 10.1128/JCM.00098-13. Epub 2013 Jan 23.

Worrisome trend of new multiple mechanisms of linezolid resistance in staphylococcal clones diffused in Italy

Floriana Campanile  1 , Gino Mongelli, Dafne Bongiorno, Chiara Adembri, Milva Ballardini, Marco Falcone, Francesco Menichetti, Antonella Repetto, Carla Sabia, Assunta Sartor, Claudio Scarparo, Carlo Tascini, Mario Venditti, Federica Zoppi, Stefania Stefani
Affiliations

Worrisome trend of new multiple mechanisms of linezolid resistance in staphylococcal clones diffused in Italy

Floriana Campanile et al. J Clin Microbiol. 2013 Apr.

Abstract

In order to assess the frequency of clinically relevant linezolid-resistant staphylococcal isolates, and the role of linezolid in maintaining and coselecting multiple resistance mechanisms (cfr, 23S rRNA, L3/L4 mutations), a prospective Italian study was performed from 2010 to 2011 to confirm the diffusion of three major multidrug-resistant clones (ST2, ST5, ST23).

PubMed Disclaimer

Figures

Fig 1
Fig 1
Snapshot of our isolates using eBurst version 3.
See this image and copyright information in PMC

References

    1. Gonzales RD, Schreckenberger PC, Graham MB, Kelkar S, DenBesten K, Quinn JP. 2001. Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid. Lancet 357:1179. - PubMed
    1. Tsiodras S, Gold HS, Sakoulas G, Eliopoulos GM, Wennersten C, Venkataraman L, Moellering RC, Ferraro MJ. 2001. Linezolid resistance in clinical isolate of Staphylococcus aureus. Lancet 38:207–208 - PubMed
    1. Stefani S, Bongiorno D, Mongelli G, Campanile F. 2010. Linezolid resistance in staphylococci. Pharmaceuticals 3:1988–2006 - PMC - PubMed
    1. Long KS, Vester B. 2012. Resistance to linezolid caused by modifications at its binding site on the ribosome. Antimicrob. Agents Chemother. 56:603–661 - PMC - PubMed
    1. Schwarz S, Werckenthin C, Kehrenberg C. 2000. Identification of a plasmid-borne chloramphenicol-florfenicol resistance gene in Staphylococcus sciuri. Antimicrob. Agents Chemother. 44:2530–2533 - PMC - PubMed

Publication types

LinkOut - more resources