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Comment
. 2013 Feb;10(1):81-5; discussion 88-92.
doi: 10.1177/1740774512469313.

Discussion of 'small-sample behavior of novel phase I cancer trial designs' by Assaf P Oron and Peter D Hoff

Bradley P Carlin  1 , Wei Zhong, Joseph S Koopmeiners
Affiliations
Comment

Discussion of 'small-sample behavior of novel phase I cancer trial designs' by Assaf P Oron and Peter D Hoff

Bradley P Carlin et al. Clin Trials. 2013 Feb.
No abstract available

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Figures

Figure 1
Figure 1
Between-run variability in n*, the number of cohorts allocated to the MTD, for the long- and short-memory versions of the logistic and NUP models in the logistic scenario. The runs were 16 cohorts long with cohort size 3.
Figure 2
Figure 2
Between-run variability in n*, the number of cohorts allocated to the MTD, for the long- and short-memory versions of the logistic and NUP models in the unsmooth scenario. The runs were 16 cohorts long with cohort size 3.
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References

    1. Berry SM, Carlin BP, Lee JJ, Müller P. Bayesian Adaptive Methods for Clinical Trials. Boca Raton, FL: Chapman and Hall/CRC Press; 2011.
    1. Carlin BP, Louis TA. Bayesian Methods for Data Analysis. 3rd. Boca Raton, FL: Chapman and Hall/CRC Press; 2009.
    1. Gelman A, Carlin J, Stern H, Rubin DB. Bayesian Data Analysis. 2nd. Boca Raton, FL: Chapman and Hall/CRC Press; 2004.
    1. Yin G, Yuan Y. Bayesian model averaging continual reassessment method in phase I clinical trials. Journal of the American Statistical Association. 2009;104:954–968.
    1. Zhong W, Carlin BP, Koopmeiners JS. Flexible link continual reassessment methods for trivariate binary outcome phase I/II trials. Journal of Statistical Theory and Practice 2013 To appear.

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