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. 2004 Jun;30(2):161-9.
doi: 10.1023/B:JOBP.0000035860.68226.22.

AM1 Study of N-2-Acetylaminofluorene bonded to Deoxyguanosine at the Minor Adduct Site

M Besson  1 , E P Batchelor
Affiliations

AM1 Study of N-2-Acetylaminofluorene bonded to Deoxyguanosine at the Minor Adduct Site

M Besson et al. J Biol Phys. 2004 Jun.

Abstract

We have computed the total energy as a function of six important torsion angles of the carcinogen N-2-acetylaminofluorene (AAF) bonded to thenitrogen N2 of deoxyguanosine using the semiempirical quantum mechanical method AM1. One global minimum and one local minimum are found separated by a modest barrier. We have computed the normal-mode frequencies of the relevant torsional motions and have determined the rate of conversion betweenthe two minima.

Keywords: N-2-ac; deoxyguanosine.

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References

    1. Nesnow S., Argus M., Bergman H., Chu K., Frith C., Helmes T., McGaughy R., Ray V., Slaga T.J., Tennant R., Weisburger E. Chemical Carcinogens. A Review and Analysis of the Literature of Selected Chemicals and the Establishment of the Gene-Tox Carcinogen Data Base. The U.S. Environmental Protection Agency Gene-Tox Program. Mutat. Res. 1988;185:1–195. - PubMed
    1. Kriek E., Miller J.A., Juhl U., Miller E.C. 8-(N-2-fluorenylacetamido) Guanosine, an Arylamidation Reaction Product of Guanosine and the Carcinogen N-acetoxy-N-2-fluorenylacetamide in Neutral Solution. Biochemistry. 1967;6:177–182. - PubMed
    1. Kriek E. Persistent Binding of a New Reaction Product of the Carcinogen N-hydroxy-N-2-acetylaminofluorene with Guanine in Rat Liver DNA in vivo. Cancer Res. 1972;32:2042–2048. - PubMed
    1. Westra J.G., Kriek E., Hittenhausen H. Identification of the Persistently Bound Form of the Carcinogen N-acetyl-2-aminofluorene to Rat Liver DNA in vivo. Chem. Biol. Interactions. 1976;15:149–164. - PubMed
    1. Yamasaki H., Leffler S., Weinstein I.B. Effect of N-2-acetylaminofluorene Modification on the Structure and Template Activity of DNA and Reconstituted Chromatin. Cancer Res. 1977;37:684–691. - PubMed