Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013:6:19-24.
doi: 10.2147/IJGM.S39065. Epub 2013 Jan 10.

Low dose aspirin therapy and renal function in elderly patients

Patience Olayinka Akinwusi  1 , Rotimi Oluyombo, Paul Sunday Ogunro, Adetunji Oladeni Adeniji, Oluyomi Olusola Okunola, Olugbenga Edward Ayodele
Affiliations

Low dose aspirin therapy and renal function in elderly patients

Patience Olayinka Akinwusi et al. Int J Gen Med. 2013.

Abstract

Purpose: To determine whether low dose aspirin has any deleterious effects on renal function in elderly patients.

Methods: We conducted a prospective pilot study of 30 Nigerians older than 60 years with various chronic ailments necessitating the use of low dose aspirin. Patients gave their consent, and institutional ethical clearance was obtained. Each patient's baseline samples at enrolment (before commencing aspirin use) served as a control, and subsequent weekly samples were compared. The weekly mean of each parameter was calculated, and the differences of means from baseline were determined, and values were compared for statistical differences with the Statistical Package for the Social Sciences, version 16.

Results: We found that a majority of patients (86.67%) had basal renal functions at chronic kidney disease stages 1 and 2. When compared with the corresponding baseline parameters, the mean weekly serum and urinary electrolytes, urea, creatinine, and uric acid parameters did not change, and the P-value did not show any statistical significance. However, there was positive statistical significance for the creatinine clearance (P = 0.025). Also, unlike in previous studies, anemia and hypoalbuminemia did not affect the renal function parameters.

Conclusion: This study did not show any deleterious effects with short-term, low dose (75 mg daily) aspirin use on kidney functions in elderly patients. However, caution should be exercised when dealing with patients in renal stages 3-5 and the very elderly, aged ≥ 80 years.

Keywords: elderly; low dose aspirin; renal functions.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Pattern of serum potassium levels of patients on low dose aspirin. Note: F = 0.53; P = 0.784.
Figure 2
Figure 2
Pattern of plasma urea of patients on low dose aspirin. Note: F = 0.63; P = 0.709.
Figure 3
Figure 3
Pattern of serum albumin of patients on low dose aspirin. Note: F = 0.19; P = 0.978.
Figure 4
Figure 4
Pattern of urinary uric acid levels of patients on low dose aspirin. Note: F = 0.50; P = 0.811.
Figure 5
Figure 5
Pattern of urinary creatinine in patients on low dose aspirin. Note: F = 0.35; P = 0.911.
Figure 6
Figure 6
Pattern of plasma creatinine levels of patients on low dose aspirin. Note: F = 0.60; P = 0.731.
Figure 7
Figure 7
Pattern of plasma uric acid levels of patients on low dose aspirin. Note: F = 0.33; P = 0.921.
Figure 8
Figure 8
Pattern of creatinine clearance of patients on low dose aspirin. Note: F = 2.48; P = 0.025.
See this image and copyright information in PMC

References

    1. Ancheta JI, Reding MJ. Stroke diagnosis and management: a multidisciplinary effort. In: Hazzard WR, Blass JP, Ettinger WH Jr, Halter JB, Ouslander JG, editors. Principles of Geriatric Medicine and Gerontology. 4th ed. New York: McGraw-Hill; 1999. p. 124.
    1. Gurwitz JH, Gore JM, Goldberg RJ, Rubison M, Chandra N, Rogers WJ. Recent age-related trends in the use of thrombolytic therapy in patients who have had acute myocardial infarction. National Registry of Myocardial Infarction. Ann Intern Med. 1996;124(3):283–291. - PubMed
    1. Silagy CA, McNeil JJ, Donnan GA, Tonkin AM, Worsam B, Campion K. Adverse effects of low-dose aspirin in a healthy elderly population. Clin Pharmacol Ther. 1993;54(1):84–89. - PubMed
    1. Krumholz HM, Radford MJ, Ellerbeck EF, et al. Aspirin in the treatment of acute myocardial infarction in elderly Medicare beneficiaries. Circulation. 1995;92(10):2841–2847. - PubMed
    1. Gurwitz JH, Avorn J, Ross-Degnan D, Lipsitz LA. Nonsteroidal anti-inflammatory drug-associated azotemia in the very old. JAMA. 1990;264(4):471–475. - PubMed

LinkOut - more resources