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Review
. 2013 Mar;14(1):17-21.
doi: 10.1016/j.prrv.2012.05.005. Epub 2012 Jun 29.

Perinatal exposure to alcohol: implications for lung development and disease

Danielle Giliberti  1 , Sowmya S Mohan, Lou Ann S Brown, Theresa W Gauthier
Affiliations
Review

Perinatal exposure to alcohol: implications for lung development and disease

Danielle Giliberti et al. Paediatr Respir Rev. 2013 Mar.

Abstract

In utero alcohol exposure dramatically increases the risk of premature delivery. However, the majority of premature and term newborns exposed to alcohol remain undetected by medical caregivers. There is a desperate need for reliable and accurate biomarkers of alcohol exposure for the term and premature newborn population. The inability to identify the exposed newborn severely limits our understanding of alcohol's pathophysiological effects on developing organs such as the lung. This chapter will review potential advancements in future biomarkers of alcohol exposure for the newborn population. We will discuss alcohol's effects on redox homeostasis and cellular development of the neonatal lung. Finally, we will present the evidence describing in utero alcohol's derangement of innate and adaptive immunity and risk for infectious complications in the lung. Continued investigations into the identification and understanding of the mechanisms of alcohol-induced alterations in the premature lung will advance the care of this vulnerable patient population.

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References

    1. Center for Disease Control and Prevention C Alcohol use among childbearing-age women - United States 1991-1999. MMWR Morbidity and Mortality Weekly Report. 2002;51:273–6. - PubMed
    1. Finer LB, Henshaw SK. Disparities in rates of unintended pregnancy in the United States, 1994 and 2001. Perspect Sex Reprod Health. 2006;38:90–6. - PubMed
    1. Grant TM, Huggins JE, Sampson PD, Ernst CC, Barr HM, Streissguth AP. Alcohol use before and during pregnancy in western Washington, 1989-2004: implications for the prevention of fetal alcohol spectrum disorders. Am J Obstet Gynecol. 2009;200:278, e1–8. - PMC - PubMed
    1. Warren KR, Hewitt BG. Fetal alcohol spectrum disorders: when science, medicine, public policy, and laws collide. Dev Disabil Res Rev. 2009;15:170–5. - PubMed
    1. Center for Disease Control and Prevention C Alcohol consumption among women who are pregnant or who might become pregnant - United States, 2002. MMWR Morbidity and Mortality Weekly Report. 2004;53:1178–81. - PubMed

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