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Editorial
. 2013 Mar;144(3):497-500.
doi: 10.1053/j.gastro.2013.01.027. Epub 2013 Jan 21.

Bariatric surgery in the era of personalized medicine

Andrew A Butler, Robert W O'Rourke
Editorial

Bariatric surgery in the era of personalized medicine

Andrew A Butler et al. Gastroenterology. 2013 Mar.
No abstract available

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Conflict of interest statement

Conflicts of interest: The authors have no relevant conflicts of interest to report.

Figures

Figure 1
Figure 1
Schematic showing the potential role of the central nervous melanocortin system in the anorectic and metabolic consequences associated with RYGB. The central nervous melanocortin system is comprised of neurons expressing pro opio melanocortin (POMC), agouti-related peptide (AgRP), or the melanocortin receptors (not shown). Studies using the LoxTB Mc4r mouse suggest that MC4Rs expressed in the paraventricular nucleus of the hypothalamus (PVN) are important for regulating satiety; the activity of MC4Rs expressed on preganglionic autonomic neurons controlling the parasympathetic and sympathetic nervous system (PNS, SNS) impacts on energy expenditure and insulin sensitivity in the periphery. RYGB is associated with altered secretion of gut peptides that changes the activity of POMC and AgRP neurons to reduce food intake and improve insulin sensitivity by increasing autonomic tone,.
See this image and copyright information in PMC

Comment on

References

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