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. 2013 Feb;19(2):218-22; quiz 353.
doi: 10.3201/eid1902.120961.

Laboratory-based surveillance for hepatitis E virus infection, United States, 2005-2012

Jan Drobeniuc  1 , Tracy Greene-Montfort, Ngoc-Thao Le, Tonya R Mixson-Hayden, Lilia Ganova-Raeva, Chen Dong, Ryan T Novak, Umid M Sharapov, Rania A Tohme, Eyasu Teshale, Saleem Kamili, Chong-Gee Teo
Affiliations

Laboratory-based surveillance for hepatitis E virus infection, United States, 2005-2012

Jan Drobeniuc et al. Emerg Infect Dis. 2013 Feb.

Abstract

To investigate characteristics of hepatitis E cases in the United States, we tested samples from persons seronegative for acute hepatitis A and B whose clinical specimens were referred to the Centers for Disease Control and Prevention during June 2005-March 2012 for hepatitis E virus (HEV) testing. We found that 26 (17%) of 154 persons tested had hepatitis E. Of these, 15 had not recently traveled abroad (nontravelers), and 11 had (travelers). Compared with travelers, nontravelers were older (median 61 vs. 32 years of age) and more likely to be anicteric (53% vs. 8%); the nontraveler group also had fewer persons of South Asian ethnicity (7% vs. 73%) and more solid-organ transplant recipients (47% vs. 0). HEV genotype 3 was characterized from 8 nontravelers and genotypes 1 or 4 from 4 travelers. Clinicians should consider HEV infection in the differential diagnosis of hepatitis, regardless of patient travel history.

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Figures

Figure
Figure
Genetic relatedness among hepatitis E virus (HEV) strains identified in hepatitis E cases, United States. Phylogenetic tree was constructed from a segment of HEV open reading frame 1 generated in MEGA5 (www.megasoftware.net) by using the neighbor-joining method. Country, year reported, and numeric or GenBank accession number assignment are denoted. Scale bar indicates genetic distance.
See this image and copyright information in PMC

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